Pfizer Corporation

Robert McKenzie Owen

David Cameron Pryde

Mifune Takeuchi

Kevin Neil Dack

Nigel Alan Swain

Robert Ian Storer

Christine Anne Louise Watson

Kiyoyuki Omoto

Christine Ann Louise Watson

The present invention relates to pyrazolopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-1H-pyrazolo[3,4-c]pyridazine derivatives of formula (I), and pharmaceutically acceptable salts thereof, wherein X, R, R, R, Rand Rare as defined in the description. The pyrazolopyridazine derivatives of the present invention modulate the activity of the GABAreceptor. They may useful in the treatment of a number of conditions, including pain and epilepsy. 

4-(biphen-3-yl)-1H-pyrazolo[3,4-c]pyridazine derivatives of formula (I) as GABA receptor modulators for use in the treatment of epilepsy and pain

The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein R, R, R, R, Rand Rare as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAreceptor. They are useful in the treatment of a number of conditions, including pain.

Imidazopyridazine derivatives as modulators of the GABAA receptor activity

The present invention relates to new sulfonamide URAT-1 inhibitor compounds of formula (I) or a pharmaceutically acceptable salt thereof: to compositions containing them, to processes for their preparation and to intermediates used in such processes, and to methods of treatment, wherein R, R, R, R, Rand Rare as defined in the description.

Chemical compounds

The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein R, R, R, Rand Rare as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAreceptor. They are useful in the treatment of a number of conditions, including pain.

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Great Abington, United Kingdom

Robert McKenzie Owen