Amgen Inc.

Robert Matthew Fesinmeyer

Jian Hua Gu

William Callahan

Rahul Rajan Kaushik

Rulin Qian

Yael Wexler-cohen

Sai Chakradhar Padala

This invention concerns a series of excipients capable of effectively reducing the viscosity of protein formulations. The viscosity reducing excipients are oligopeptides (e.g., dipeptides, tripeptides) comprising at least one arginine. The peptides may also include basic or acidic or hydrophilic or hydrophobic/aromatic amino acids. An arginine residue may be either at the amino or the carboxyl end of the oligopeptide.

Excipients to reduce the viscosity of antibody formulations and formulation compositions

Protein formulations and methods of making and using such formulations are provided herein. The formulation can be an ophthalmic formulation, such as for intravitreal administration. In some embodiments, the formulation comprises a VEGFR-Fc fusion protein, such as aflibercept.

VEGFR-Fc fusion protein formulations

Growing community of inventors

Newbury Park, CA, United States of America

Robert Matthew Fesinmeyer