Bristol-myers Squibb Compnay

Other

Thomas Jefferson University

Robert Martin Townsend

Francisco A Leon

Jaclyn Rae Espinosa

Catherine Aversa Fleener

Allan D Kirk

Yuping Qiu

Steven G Nadler

Fred Christopher Zusi

Robert Korngold

James R Burke

Catherine A Fleener

Robert J Peach

Charles Gordon Todderud

The present invention provides methods utilizing changes in CD4+CD57+ T cells levels for determining the susceptibility of a transplant patient or patient in need thereof to costimulation blockade resistant rejection. These methods are useful for identifying effective drug regimens for the treatment of immune disorders associated with graft transplantation and/or maintenance of a transplant.

Methods for treating costimulation blockade resistant rejection

Methods for treating patients at risk for costimulation blockade resistant rejection with belatacept

The present invention discloses a method for assaying the binding of L104EA29YIg to a receptor. The receptor is preferably CD86 or CD80. The present invention also discloses antibodies to be used in the assay, as well as hybridomas expressing the antibodies.

Anti-CD86 antibody

CD86 and CD80 receptor competition assays

The present invention describes methods of preventing and treating inflammatory and immune-related diseases or disorders using inhibitors of I&#x3ba;B kinase (IKK). Also described are IKK inhibitors effective for the prevention and treatment of inflammatory and immune-related diseases or disorders, as demonstrated in vivo. Further embodiments of the present invention relate to a specific IKK inhibitors, 4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a) quinoxaline and compounds of formula (I), salts thereof, and pharmaceutical compositions.

Methods of treating inflammatory and immune diseases using inhibitors of I&#x3ba;B kinase (IKK)

Peptides which mimic a loop on the &ggr;-chain that either interact with a cytokine or a &ggr;-chain partner receptor chain of a heterodimeric cytokine receptor are disclosed. The peptides consist of 5-25 amino acids and inhibit signal transduction mediated by cytokine:receptor binding of cytokines that bind to receptors that comprise a &ggr;-chain. Pharmaceutical compositions that comprise the peptides are disclosed. Methods of inhibiting signal transduction mediated by cytokine:receptor binding of cytokines that bind to receptors that comprise a &ggr;-chain, methods of inhibiting cytokine mediated cell growth, proliferation, function or activity, methods of treating patients suffering from a disease disorder or condition characterized by cytokine mediated cell growth, proliferation, function or activity and methods of preventing a condition characterized by cytokine mediated cell growth, proliferation, function or activity are disclosed.

Peptide mimics of the cytokine receptor common &ggr; chain and methods and compositions for making and using the same

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Boothwyn, PA, United States of America

Robert Martin Townsend