Harvard College

The Brigham and Women's Hospital, Inc.

Children's Medical Center Corporation

Robert M Westervelt

Thomas Hunt

Ania Bleszynski

Donald Elliot Ingber

Howard A Stone

Christopher C Thompson

Rick A Rogers

Keith L Obstein

Alex Nemiroski

John W Hutchinson

Jonathan Aguilar

Keith Brown

Shannon Xia

Brendan Clifford

Tom P Hunt

Rex G Beck

An apparatus preventing hearing loss having a body made of soft compliant material having first and second ends and a channel extending therethrough, an acoustically limp material adjacent one end of the body with the acoustically limp material having a hole therein aligned with the channel extending through the body, component film, or other structure covering or sealing the opening in the acoustically limp material. The film may be a high-strength polymer less than 10 micrometers thick. A plurality of channels may extend through the body and a plurality of corresponding holes may be provided in the acoustically limp material. The film covers or seals the holes in the acoustically limp material. The film may behave like a flap to close in response to high energy sound waves. The flap shuts from the high intensity shock wave. The body may have shape to fit in an ear canal.

Nano-otologic protective equipment for impact noise toxicity and/or blast overpressure exposure

A system and method for monitoring a physical parameter of a subject is provided. The system may include a casing with a sensor coupled to the casing. The sensor may be configured to detect a physical parameter of the subject. The physical parameter may include a chemical parameter of the subject. The system includes an endoscopic clip coupled to the casing and may include a wireless transmitter for transmitting a signal via a wireless medium. The signal encodes the physical parameter of the subject detected by the sensor and the wireless transmitter is electronically connected to the endoscopic clip. The system may further include a monitor configured to communicate with the wireless transmitter for receiving the signal encoding the physical parameter of the subject.

System and method for wireless biosensor monitoring

A miniaturized, integrated, microfluidic device pulls materials bound to magnetic particles from one laminar flow path to another by applying a local magnetic field gradient. The device removes microbial and mammalian cells from flowing biological fluids without any wash steps. A microfabricated high-gradient magnetic field concentrator (HGMC) is integrated at one side of a microfluidic channel. When magnetic particles are introduced into one flow path, they remain limited to that flow path. When the HGMC is magnetized, the magnetic beads are pulled from the initial flow path into the collection stream, thereby cleansing the fluid. The microdevice allows large numbers of beads and materials to be sorted simultaneously, has no capacity limit, does not lose separation efficiency as particles are removed, and is useful for cell separations from blood and other biological fluids. This on-chip separator allows cell separations to be performed in the field outside of hospitals and laboratories.

Device and method for combined microfluidic-micromagnetic separation of material in continuous flow

Dielectrophoretic (DEP) tweezers apparatus and methods for various applications, including particle trapping. Two electrodes are disposed on or otherwise constitute an elongated object forming a tip. A voltage is applied across these electrodes to produce a non-uniform electromagnetic field proximate to the tip thereby creating a dielectrophoretic trap. Once trapped, a particle may be moved to desired locations via manipulation of the elongated object or the medium in which the particle is located. Multiple DEP tweezers apparatus may be arranged to form arrays of tips capable of respectively generating local electromagnetic fields confined to the tips. Such DEP arrays may be employed in nanofabrication processes involving nanolithography or nano-manipulation, as well as data storage and retrieval applications.

Dielectrophoretic tweezers apparatus and methods

Dielectrophoretic (DEP) tweezers apparatus and methods for various applications, including particle trapping. Multiple electrodes (e.g., two or three) are disposed on or otherwise constitute an elongated object forming a tip. Exemplary electrode configurations include, but are not limited to, coaxial and triaxial arrangements. A voltage is applied across these electrodes to produce a non-uniform electromagnetic field proximate to the tip thereby creating a dielectrophoretic trap. Once trapped, a particle may be moved to desired locations via manipulation of the elongated object or the medium in which the particle is located. Multiple DEP tweezers apparatus may be arranged to form arrays of tips capable of respectively generating local electromagnetic fields confined to the tips. Such DEP arrays may be employed in nanofabrication processes involving nanolithography or nano-manipulation, as well as data storage and retrieval applications.

A novel GaAs/AlGaAs piezoelectric FET strain sensing transducer is disclosed. An embodiment of the strain sensing transducer includes a single piezoelectric crystal structure forming a cantilever arm and having an FET at the fixed cantilever base. Circuitry connected to measure changes in the conductivity of the FET Channel provides an output signal indicative of the measured strain produced by small forces which alter the conductance of the FET due to piezoelectric effects.

Semiconductor piezoelectric strain measuring transducer

Growing community of inventors

Lexington, MA, United States of America

Robert M Westervelt