Mesoscale Technologies, Llc.

Clinical Micro Sensors, Inc.

Osmetech Technology, Inc.

Robert M Umek

Paula Denney Eason

Eli N Glezer

Jacob N Wohlstadter

George B Sigal

John H Kenten

Niranjan Y Sardesai

James L Wilbur

Jeff D Debad

Changjun Yu

Pankaj Oberoi

Michael Tsionsky

Hans Biebuyck

Jost G Vielmetter

Kent Johnson

Bruce D Irvine

Gary Fife Blackburn

Robert H Terbrueggen

Anu Mathew

Douglas Woods

Gargi Maheshwari

Described are assay methods, modules and kits useful in the detection, treatment and/or prevention of dementia and related conditions, including but not limited to Alzheimer's disease and mild cognitive disorders.

Antibody array for measuring a panel of amyloids

The invention relates to the use of signal processing methods in order to achieve higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.

Signal detection techniques for the detection of analytes

Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

Methods and apparatus for conducting multiple measurements on a sample

Improved systems, system components, and methods for performing assays involving biological membranes and/or components thereof. Preferred luminescence test measurements are conducted using an assay module with integrated electrodes having biological membranes and/or components thereof immobilized thereon with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

Assay electrode having immobilized lipid/protein layers, methods of making the same and methods of using the same for luminescence test measurements

The present invention is directed to methods and compositions for the use of self-assembled monolayers to electronically detect nucleic acids, particularly alterations such as nucleotide substitutions (mismatches) and single nucleotide polymorphisms (SNPs).

Sequence determination of nucleic acids using electronic detection

Growing community of inventors

Silver Spring, MD, United States of America

Robert M Umek