Varian Medical Systems, Inc.

Varian Medical Systems Technologies, Inc.

University of Arizona

Montefiore Medical Center

Robert M Sutherland

Hassan Mostafavi

Majid L Riaziat

Andrew G Jeung

George A Zdasiuk

Edward J Seppi

Felix Fernando

Larry D Partain

John M Boone

David H Humber

Stavros Prionas

Bruce Bondurant

David F O'Brien

Kathy A McGovern

Michael C Green

Chandan Guha

Alan A Alfieri

Steven Bandy

Jayanta Roy-Chowdury

Disclosed are methods of obtaining an expanded population of mammalian ex vivo cells for treating a mammalian subject by (a) administering to a subject an effective amount of an agent that confers a growth disadvantage to at least a subset of endogenous cells at the site of engraftment; (b) administering to the subject an effective amount of a mitogenic stimulus for the ex vivo cells; and (c) administering the ex vivo cells to the subject, wherein the ex vivo cells engraft at the site and proliferate to a greater extent than the subset of endogenous cells, to repopulate at least a portion of the engraftment site with the ex vivo cells. The repopulated cells can be harvested or left at the engraftment site. Methods of treating brain injury in a subject by engrafting ex vivo cells at the site of injury are also described.

Preparative regimen for engraftment, growth and differentiation of non-hematopoeitic cells in vivo after transplantation

The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.

Radiation sensitive liposomes

An image acquisition device having a photoconductor, a substrate including a detector array and an interlayer between the photoconductor and the substrate is disclosed. The interlayer is formed of molecules having a first ligand selectively binding the substrate and a second ligand selectively binding the photoconductor.

Apparatus of photoconductor crystal growth

A method of imaging a patient's uncompressed region of interest using X-ray cone beam computed tomography or cone beam digital tomography comprises the step of introducing an effective amount of a contrast agent to the uncompressed region of interest. A system for imaging a patient's uncompressed region of interest using cone beam computed tomography (CBCT) or cone beam digital tomography (CBDT) comprises an X-ray source transmitting an X-ray to the uncompressed region of interest, an image acquisition system acquiring a plurality of two-dimensional projection images data for a CBCT or CBDT data set with at least one of the projection images acquired in 35 milliseconds or less, and a processor generating a three-dimensional computed tomography image data set resolving voxels with dimensions of 0.4 mm or less in at least two orthogonal directions.

Contrast-enhanced cone beam X-ray imaging, evaluation, monitoring and treatment delivery

A method and system for monitoring breathing movement of a subject is disclosed. A method and system for detecting and predictably estimating regular cycles of breathing movements is disclosed. Another disclosed aspect of the invention is directed to detect and report irregularity of breathing activity of an infant, such as cessation and non-periodicity, which suggests a likelihood of SIDS.

Method and system for monitoring breathing activity of a subject

A method and system for monitoring breathing movement of an infant is disclosed. A method and system for detecting and predictably estimating regular cycles of breathing movements is disclosed. Another disclosed aspect of the invention is directed to detect and report irregularity of breathing activity of an infant, such as cessation and non-periodicity, which suggests a likelihood of SIDS.

An apparatus and method to implement and control a plurality of minimally invasive therapies in the treatment of a medical condition of a patient based on a treatment plan. The apparatus includes a template which has a plurality of electrically conductive apertures, a plurality of needles which have a plurality of sensors and a processor. At least one of the needles is inserted through and in electrical contact with one of the conductive apertures. The processor is electrically coupled to the template and is configured to send signals to and receive signals from at least one of the sensors of at least one of the needles inserted through one of the conductive apertures. The processor is further configured to process the signals received from the sensor in relation to the treatment plan and to adjust the signals sent to the sensor to control the treatment.

Multipurpose template and needles for the delivery and monitoring of multiple minimally invasive therapies

Growing community of inventors

Menlo Park, CA, United States of America

Robert M Sutherland