University of California

Axys Pharmaceuticals, Inc.

Other

Arris Pharmaceutical Corporation

Fundacion Ciencia Para La Vida

Robert M Stroud

Thomas E Jenkins

James M Clark

Bradley A Katz

Kevan M Shokat

Arvin C Dar

Peter Walter

Chao Zhang

William R Moore

Alexei Korennykh

Kyle C Elrod

Janet Finer-Moore

Pascal Egea

Andrei Korostelev

Sebastian Bernales

Disclosed herein are, inter alia, compositions for modulating Ire1, Src, or Abl, methods for identifying modulating activity in test compounds, and methods for treating diseases caused by the activity or inactivity of Ire1, Src, or Abl.

Methods and compositions for modulating Ire1, SRC and ABL activity

Methods and compositions for modulating IRE1, SRC, and ABL activity

The present invention relates to serine protease inhibitors having a P site binding moiety and a divalent cation(s) chelating moiety which are pre-prepared as divalent cation(s) complexes or combined with the serine protease in the presence of divalent cation(s) and methods for identifying and using the inhibitors. The compounds are shown to have high inhibitory activity when complexed to divalent cation(s) and are useful in various processes associated with serine protease isolation and inhibition.

Metal mediated serine protease inhibitors

A method is presented for determining if the inhibition of metal mediated serine proteases can be potentiated by cobalt or zinc ions.

Potentiating metal mediated serine protease inhibitors with cobalt or zinc ions

Serine protease inhibitors are provided comprising compounds having a P site binding moiety and a divalent cation(s) chelating moiety which are pre-prepared as divalent cation(s) complexes or combined with the serine protease in the presence of divalent cation(s). The compounds are shown to have high inhibitory activity when complexed to divalent cation(s) and find use in various processes associated with serine protease isolation and inhibition.

Metal complexed serine protease inhibitors

Growing community of inventors

San Francisco, CA, United States of America

Robert M Stroud