Leland Stanford Junior University

University of California

Robert M Sapolsky

H Craig Heller

Dennis A Grahn

Qun-Yong Zhou

Edward S Mocarski, Jr

Michelle Y Cheng

Alex G Lee

Dora Yuk-wai Ho

Lisa Share

The present invention relates to a method of identifying agents that modulate prokineticin receptors, particularly, in the brain. Such agents are useful in the treatment of cerebrovascular diseases, including cerebral ischemia, cerebral hemorrhage, ischemic stroke, hemorrhagic stroke, and ischemic reperfusion injury. Additionally, such agents are useful to treat seizure disorders, such as epilepsy.

Methods for treating cerebrovascular disease comprising administering an agent that inhibits prokineticin receptor activity

Low-cost, reliable, easy to use device and method identifies potential drowning or near-drowning events (i.e. a submerged inert human) in a timely manner, provides the precise location of the event, and issues an alert that such an event is in progress. Device is optionally networked to remote monitoring station.

Sonar based drowning monitor

Defective herpes simplex virus (HSV) vectors have been used to express a glucose transporter gene. The vectors were propagated using HSV conditional mutants. The efficacy of this system in vivo was tested by microinjection of the vector into adult rat hippocampus and measurement with [.sup.14 C]2-deoxyglucose uptake autoradiography, as well as measurement of kainic acid-(KA-) induced lesions. The vector significantly enhanced glucose transport and decreased neuronal damage in regions near the site of injection without causing adverse cytopathology. Neuroprotection was conferred by injecting the vector prior to, concurrently with, and following neuronal insult.

Gene transfer using herpes virus vectors as a tool for neuroprotection

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San Francisco, CA, United States of America

Robert M Sapolsky