The Governing Council of the University of Toronto

Other

Sunnybrook Health Sciences Centre

Ontario Research Foundation

Sunnybrok Health Sciences Centre

Robert M Pilliar

Paul Santerre

Cari Marisa Whyne

Jeffrey Allan Fialkov

Eran Regev

J Paul Santerre

Rita A Kandel

Phillip A Watson

Douglas A Deporter

Jenshong Hong

Marc Grynpas

The present disclosure discloses a bone stabilization device (also referred to as a bone tape), which includes a composite flexible construct including a rigidifiable biocompatible sheet structure having first and second opposed surfaces. A biocompatible cement is located on the first surface. In use the composite flexible construct is applied to a bone with the cement contacted directly to the bone. The cement is made of a material that, once adhered to the bone, is curable to mechanically and/or ionically bond to the sheet structure and to chemically bond to the bone to achieve a permanent bond. The bone tape allows simultaneous alignment and stabilization of multiple articulated fragments for successful 3D reconstruction of shattered bones. Initial flexibility and translucency provided by the bone tape can facilitate the temporary stabilization and alignment adjustment of multiple fragments, prior to permanent rigid bonding.

Bone stabilization device and method of production

A sintering schedule to allow the reliable formation of inorganic or ceramic materials, exemplified using porous calcium polyphosphate samples to be used for forming novel implants for bone interfacing applications. The key to the successful definition of the process was the determination of the factors affecting the crystallization temperature of the powders that are gravity sintered to form porous samples of desired density and with a pore size range suitable for the particular application. The method involves applying a sintering procedure to a packed amorphous inorganic powder which gives control over densification and includes choosing sintering temperatures and times sequentially that correspond to the inorganic material being amorphous but having a viscosity to develop significant sinter necks between adjacent powder particles by a viscous flow sintering mechanism while maintaining a desired open-pored structure, followed by a second temperature at which crystallization of the packed amorphous inorganic powder occurs and during which slower diffusion-related mechanisms control sinter neck growth and densification to give a substantially crystalline porous, inorganic structure. In addition, interpenetrating phase composites of biodegradable organic polymers throughout the porous calcium polyphosphate samples were formed and resulted in the development of novel composites with attractive strength and toughness. These materials hold promise for formation of biodegradable fracture fixation implants and degradable anchoring systems for temporary stabilization of bone-interfacing implants designed for fixation by bone ingrowth.

Method of manufacture of porous inorganic structures

Resorbable implant biomaterial made of condensed calcium phosphate

There is disclosed an implant for anchoring in bone and/or fibrous connective tissue and to which a prosthesis such as a dental bridge may be connected through connecting components. The implant is of tapered design defining a wide top portion for connection to the connecting components and a tapered body comprising upper and lower regions. The lower bone-engaging region of the implant is provided with a porous surface into which bone may grow thereby anchoring the implant. The upper region of the implant has a surface suitable for bone attachment which is different from the surface of the lower region. In one embodiment, the upper portion has a larger taper angle than the rest of the implant for increased stability and stress transfer to the surrounding bone. In another embodiment, the surface of the upper region is coated with a bioreactive coating to allow direct bonding of bone and/or soft connective tissue (gingival tissue) thereby inhibiting epithelial migration apically.

Porous surfaced implant

A surgical prosthetic device or implant is disclosed consisting of a coherent metal substrate and a pure metal porous coating. The pure metal porous coating is formed by thermal decomposition of a coating of thermally-decomposable metal compound particles and sintering of the metal particles so formed. The surface of the device or implant is irregular but the porosity is substantially uniformly distributed throughout the coating. The coating is strongly adherent to the substrate and supports the ingrowth of bone tissue for fixation of the device or implant in the body. Such coating also supports the ingrowth of fibrous tissue for the attachment of tendons and ligaments to the device.

Surgical prosthetic device or implant having pure metal porous coating

Growing community of inventors

Toronto, Canada

Robert M Pilliar