The University of Texas System

Rutgers, the State University of New Jersey

Other

University of California

The Scripps Research Institute

Robert M Krug

Karen Y Twu

Gaetano T Montelione

Rong Xiao

Kalyan Das

Edward Arnold

Rei-Lin Kuo

Li-Chung Ma

LiChung Ma

Ethan Bier

Michael Oldstone

John R Teijaro

Meghana Malur

Xiao Yan Qian

Yin Cuifeng

Ma Lichung

Margery Smelkinson

The present invention includes compositions, methods and systems to isolate and characterize novel antiviral agents by contacting the antiviral agent with the F2F3 zinc fingers of a CPSF30 protein and an Influenza A NS1A protein; and determining whether the binding between the CPSF30 protein and the Influenza A NS1A protein is reduced.

Development of influenza A antivirals

Novel models of interactions of the Nonstructural Protein of influenza A and influenza B viruses (NS1A and NS1B, respectively) with dsRNA are presented. On the basis of the models, novel recombinant viruses and vaccines against influenza A and influenza B viruses are provided.

Compositions and vaccines against influenza A and influenza B infections

Method and composition for protection and treatment against influenza viral infection by modulating the activity of at least one essential host signaling pathways, including the Hedgehog (Hh), the Bone Morphogenetic Protein (BMP), the Notch (N) signaling pathways or combinations thereof, which activity is altered by the viral protein NS1. The method and composition comprise use of a compound that modulates at least one of these essential host signaling pathways for preventing or controlling symptoms associated with influenza viral infection. The method or composition can also be used either alone or in combination with other therapeutic agents for treating or protecting against influenza infection, and associated syndromes.

Protection and treatment against influenza infection

The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.

Influenza A virus vaccines and inhibitors

The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF 30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.

A chimeric nucleic acid molecule encoding an NS1-Rev fusion protein having Rev function inhibitory activity.

Chimeric nucleic acids and proteins for inhibiting HIV-1 expression

Growing community of inventors

Austin, TX, United States of America

Robert M Krug