Nps Pharmaceuticals, Inc.

Fmc Corporation

Robert M Kral, Jr

Karen J Krapcho

Janice H Johnson

John Randolph Jackson

Bradford C VanWagenen

J R Jackson

Eric G DelMar

Eric Delmar

This invention relates to the purification of a group of insecticidally effective toxins isolated from the wasp, Bracon hebetor, characterized by their neurotoxic effect on insect pest and low mammalian toxicity. The cDNA sequences for two of these toxins have been isolated, and the complete coding sequence is provided. This invention also discloses methods for producing recombinant toxins, as well as methods of utilizing these toxins as insecticidal agents.

16 KDA insecticidal toxin from bracons hebetor, nucleic acids encoding

Insecticidal toxins from Bracon hebetor nucleic acid encoding said toxin

This invention provides a family of insecticidally effective proteins and particular members of that family which may be isolated from the venom of the spider Phidippus audax, DNA encoding such proteins, insecticidal compositions of these proteins or the DNA encoding them, and methods for controlling invertebrate pests. Recombinant expression vectors and host cells and methods for producing insecticidally effective peptides are also provided.

Insecticidally effective peptides isolatable from phidippus spider venom

This invention provides a family of insecticidally effective peptides which may be isolated from Tegenaria spider venom, DNA encoding such insecticidally effective peptides and methods for controlling invertebrate pests.

Insecticidally effective peptides

This invention provides a family of insecticidally effective proteins and particular members of that family which may be isolated from the venom of the spider Filistata hibernalis, DNA encoding such proteins, insecticidal compositions of these proteins or the DNA encoding them, and methods for controlling invertebrate pests. Recombinant expression vectors and host cells and methods for producing insecticidally effective peptides are also provided.

Recombinant expression of insecticidally effective spider toxin

This invention relates to the purification of a family of insecticidally effective peptides isolated from the spider, Calisoga sp., characterized by their neurotoxic effect on insect pest and low mammalian toxicity. The cDNA sequences for three of these peptides have been isolated, and the complete coding sequence is provided. This invention also discloses methods for producing recombinant peptides, as well as methods of utilizing these peptides as insecticidal agents.

Insecticidal peptides from spider venom

This invention relates to an insecticidally effective peptide isolated from the spider, Segestria sp., characterized by its paralytic effect on insect pests and low mammalian toxicity. This invention also discloses methods for producing recombinant peptides, as well as methods of utilizing these peptides as insecticidal agents.

Insecticidal peptides from Segestria sp. spider venom

The invention provides insecticidally effective peptides isolatable from Diguetia spider venom, methods for preparing and using insecticides, and DNA encoding such insecticidally effective peptides.

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Salt Lake City, UT, United States of America

Robert M Kral, Jr