Bristol-myers Squibb Compnay

Other

E. R. Squibb Sons, Inc.

Bristol Meyers Squibb Company

Robert M Johnston

Steven L Goldberg

Ramesh N Patel

Venkata B Nanduri

Paul M Cino

Amit Banerjee

Laszlo J Szarka

William John Winter

John J Venit

Jerome L Moniot

Animesh Goswami

Sushil K Srivastava

Shankar Swaminathan

Gerard Crispino

Neal G Anderson

David A Lust

Thomas P Tully

Mary Jo Donovan

Linda Chu

K David Mirfakhrae

This invention relates to isolated or recombinant N-carbobenzyloxy-deprotecting enzyme polypeptides that catalyze the removal of carbobenzyloxy from carbobenzyloxy-protected amino acids and alcohols. Also related are isolated nucleic acids encoding N-carbobenzyloxy-deprotecting enzyme polypeptides thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using the polypeptides in various reactions for industrial or pharmaceutical applications.

N-carbobenzyloxy (N-CBZ)-deprotecting enzyme and uses therefor

This invention relates to isolated or recombinant N-CBZ-deprotecting enzyme polypeptides that catalyze the removal of CBZ from CBZ-protected amino acids and alcohols, and variants, modifications, and fragments thereof. Also related are isolated nucleic acids encoding N-CBZ-deprotecting enzyme polypeptides, and variants, modifications, and fragments thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using polypeptides in various reactions for industrial or pharmaceutical applications.

N-carbobenzyloxy (N-CBZ)-deprotecting enzyme

This invention relates to isolated or recombinant N-carbobenzyloxy-deprotecting enzyme polypeptides, and variants and fragments thereof, that catalyze the removal of carbobenzyloxy from carbobenzyloxy-protected amino acids and alcohols. Also related are isolated nucleic acids encoding N-carbobenzyloxy-deprotecting enzyme polypeptides, and variants, and fragments thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using the polypeptides in various reactions for industrial or pharmaceutical applications.

This invention relates to a recombinantformate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also related are isolated nucleic acids encodingFDH polypeptides, and fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated, recombinantFDH polypeptides, and fragments and variants thereof, and antibodies that specifically bind toFDH polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolatedFDH nucleic acids, polypeptides, and antibodies, and methods of usingFDH in various reactions for industrial or pharmaceutical applications.

Pichia pastoris formate dehydrogenase and uses therefor

This invention relates to an novel2-ketoreductase useful for the synthesis of chiral alcohols. Also related are isolated nucleic acids encoding2-ketoreductase enzymes, and enzyme fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated2-ketoreductase polypeptides, and fragments and variants thereof, and antibodies that specifically bind to2-ketoreductase polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated2-ketoreductase nucleic acids, polypeptides, and antibodies, and methods of using2-ketoreductase in various reactions for industrial or pharmaceutical applications.

Gluconobacter oxydans 2-ketoreductase enzyme and applications thereof

A modular system for assembling a storage unit is provided which includes a plurality of panels and different connectors. The system allows for subdividing spaces which may feature walls, floors, ceilings, etc. at varying angles or in areas having irregular contours. Additionally, the connectors are simple recesses and protrusions which allow for easy assembly and disassembly of the storage unit.

Method and apparatus for providing a modular storage system

The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of &ggr;-secretase useful in the treatment of Alzheimer's disease.

Stereoselective reduction of substituted acetophenone

The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.

Enzymatic oxidative deamination process

An ophthalmic applanator for treatment of corneal lamellar flaps/caps includes a disc having a concave bottom surface with a curvature flatter than the curvature of the external surface of the cornea of the eye and steeper than the curvature of the surface of the sclera of an eye and a concave or convex top surface. The radius of curvature of the bottom surface produces a radiating pressure of higher magnitude centrally than peripherally, but is also curved sufficiently to minimize the risk of excessive indentation of the cornea. The convex or concave upper surface reduces reflection from the operating microscope.

Ophthalmic applanator

Nucleic acid sequences, particularly DNA sequences, coding for all or part of a lipase of Pseudomonas fluorescens, wherein said lipase has the amino acid sequence encoded by the nucleotide sequence of the BamHI/HindIII insert of the plasmid pRJ-Ltac1 from Escherichia coli BL21/pRJ-Ltac1 deposited with the American Type Culture Collection, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of a lipase of Pseudomonas fluorescens, wherein said lipase has the amino acid sequence encoded by the nucleotide sequence of the plasmid pRJ-Ltac1 from Escherichia coli BL21/pRJ-Ltac1 BamHI/HindIII insert of deposited with the American Type Culture Collection, and methods for producing these polypeptides.

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Whitehouse Station, NJ, United States of America

Robert M Johnston