Massachusetts Institute of Technology

The Cleveland Clinic Foundation

Robert M Cothren

Richard P Rava

Michael S Feld

Rebecca Rae Richards-Kortum

Carter Kittrell

Ramachandra Rac Dasari

Joseph J Baraga

Lucene Tong

Paola Taroni

Kyungwon An

Young D Park

Anand V Mehta

Gregory Zuccaro, Jr

Alexandre Purper Brandao

A system and method for automatically staging regional lymph nodes under the TNM classification system using textural analyses of endoscopic ultrasound images. N stage for a lymph node is determined by analyzing the organization of the texture of a region corresponding to the node on a digitized ultrasound image. Specifically, Haralick's difference entropy and correlation textural features are calculated and compared to predetermined reference values to predict whether the lymph node is benign or malignant. Also, the cross-sectional area of the node is determined and used to make an N staging determination. An application of the present invention is staging of esophageal lymph nodes in the diagnosis and treatment of esophageal carcinoma using endoscopic ultrasound images.

System and method for staging regional lymph nodes using quantitative

A method for laser induced fluorescence of tissue in which laser radiation is used to illuminate and induce fluorescence in the tissue under study to determine the chemical composition or pathologic condition of tissue. The laser radiation and the retrieved fluorescing radiation can be conveyed through a catheter using an array of optical fiber. The fluorescence spectrum of the tissue can be displayed and analyzed to obtain information regarding the chemical composition and medical condition of the tissue inside the human body.

Method for laser induced fluorescence of tissue

Growing community of inventors

Cleveland Heights, OH, United States of America

Robert M Cothren