Wyeth

Robert Lewis Vogel

Annmarie Louise Sabb

Gregory Scott Welmaker

James Albert Nelson

Joan E Sabalski

Sharon J Rosenzweig-Lipson

Magid A Abou-Gharbia

Gary Paul Stack

Amedeo A Failli

Panolil C Raveendranath

Reinhardt Bernhard Baudy

Sreenivasulu Megati

Madelene M Antane

Anita Wai-Yin Chan

Deborah Ann Evrard

Jianxin Ren

Lalitha Krishnan

Yanfang Li

Charles Guinosso

Michael D Smith

Antonia Nikitenko

Jean Yi-ching Sze

Charles John Stanton, Iii

Compounds of formula 1 or pharmaceutically acceptable salts thereof are provided: which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.

Substituted indolizines and derivatives as CNS agents

The present invention provides cycloalkylfused indole, benzothiophene, benzofuran, and indene derivatives, and methods for using them to, for example, treat, prevent and/or ameliorate central nervous system diseases by antagonizing 5-HTreceptors and modulating serotonin levels.

Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives

This invention provides compounds of the formula: wherein Rand Rare each, independently, H, alkyl, cycloalkyl, &#x2014;CH-cycloalkyl, alkoxy, halogen, fluorinated alkyl, &#x2014;CN, &#x2014;NH&#x2014;SO-alkyl, &#x2014;SO&#x2014;NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated alkoxy, acyl, or phenoyl or thiophenoyl; Rand Rare each, independently, H, alkyl or cycloalkyl; Ris H or alkyl; Ris H or; and the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions and methods utilizing these compounds for the treatment or prevention of disorders including obsessive-compulsive disorder, depression, anxiety, generalized anxiety disorder, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.

Cyclohepta[b][1,4]diazepino[6,7,1,-hi]indoles and derivatives

This invention provides compounds of formula I having the structure wherein: Rand Rare H, alkyl, cycloalkyl, alkoxy, halogen, fluorinated alkyl, &#x2014;CN, &#x2014;NH&#x2014;SO-alkyl, &#x2014;SO&#x2014;NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated, acyl, or aroyl; R, Rare H, alkyl, cycloalkyl or &#x2014;CH-cycloalkyl; Ris H or alkyl; Ris H or alkyl; and wherein the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof, as well as methods for using these compounds to treat central nervous system disorders, including obsessive-compulsive disorder, depression, anxiety, generalized anxiety disorder, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.

Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives

This invention provides compounds of the formulae: wherein:

Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives

This invention provides compounds of the formula:wherein Rand Rare each, independently, H, alkyl, cycloalkyl, &#x2014;CH-cycloalkyl, alkoxy, halogen, fluorinated alkyl, &#x2014;CN, &#x2014;NH&#x2014;SO-alkyl, &#x2014;SO&#x2014;NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated alkoxy, acyl, or phenoyl or thiophenoyl; Rand Rare each, independently, H, alkyl or cycloalkyl; Ris H or alkyl; Ris H or; and the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions and methods utilizing these compounds for the treatment or prevention of disorders including obsessive-compulsive disorder, depression, anxiety, generalized anxiety disorder, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.

Cyclohepta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives

Processes for preparation of cyclopenta&lsqb;b&rsqb;&lsqb;1,4&rsqb;diazepino&lsqb;6,7,1-hi&rsqb;indoles and derivatives

Cyclopenta&lsqb;b&rsqb;&lsqb;1,4&rsqb;diazepino&lsqb;6,7,1-hi&rsqb;indoles and derivatives

Cycloocta&lsqb;b&rsqb;&lsqb;1,4&rsqb;diazepino&lsqb;6,7,1-hi&rsqb;indoles and derivatives

&lsqb;1,4&rsqb;diazepino &lsqb;6,7,1-jk &rsqb;carbazoles and derivatives

Growing community of inventors

Collingswood, NJ, United States of America

Robert Lewis Vogel