Johns Hopkins University

Ústav Organické Chemie a Biochemie Av {hacek Over (c)}r, V.v.i.

Robert Leone

Barbara S Slusher

Pavel Majer

Jonathan David Powell

Lukas Tenora

Judson Englert

Andrej Jancarik

Andrei Jancarik

Jonathan Powell

The disclosure provides methods of treating cancer in a subject or preventing a relapse or reducing the incidence of relapse of cancer in a subject in remission, comprising administering to the subject: (a) a therapeutically effective amount of an immunotherapeutic agent, e.g., an immune checkpoint blockade therapy, an adoptive cellular therapy, a marrow-infiltrating lymphocytes, an adenosine A2aR inhibitor, or an antibody; and (b) a compound having formula (I): and the pharmaceutically acceptable salts thereof, wherein R, R, R', and X are as defined as set forth in the specification. Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON).

Methods for cancer and immunotherapy using prodrugs of glutamine analogs

Growing community of inventors

Lutherville, MD, United States of America

Robert Leone