University of Georgia Research Foundation Inc

The General Hospital Corporation

Robert Lance Wells

Kelley Wilson Moremen

James Michael Pierce

J Michael Pierce

Stephen Dalton

Ronald Carl Orlando

Galit Alter

William S York

James A Atwood, Iii

Wen-Han Yu

Michael Tiemeyer

Kelley W Moremen

Systems and methods have been developed to design and engineer glycan dynamics to improve immunogen antigenicity. These include systems for identify glycosylation sites that that impact binding of antibodies to the immunogen, and modifying the glycan profiles on these glycosylation sites to synthesize novel immunogens, antibodies and vaccines. Then, the machine learning algorithm may output data relating to the glycosylation sites that are determinant or likely impact the binding affinity of the variants to the one or more antibodies.

Synthesizing vaccines, immunogens, and antibodies

The present invention relates to a method of isotopically labeling glycans and in facilitating high throughput quantitative/comparative analysis of glycomic compositions of biological cells. The method is applicable inter alia for identifying differentiated cells and their glycomic characteristics, differentiation conditions, disease and/or therapeutic progression, diagnosing disease states, determining drug activity, establishing manufacturing efficiencies and for determining the half-life of glycans in cells.

Vivo isotopic labeling method for quantitative glycomics

Growing community of inventors

Athens, GA, United States of America

Robert Lance Wells