Leland Stanford Junior University

Proteus Digital Health, Inc.

Magarray, Inc.

Robert L White

Shan X Wang

Nader Pourmand

Chris D Webb

Guanxiong Li

Mark Zdeblick

George M Savage

Sebastian J Osterfeld

Heng Yu

Olivier K Colliou

Lawrence W Arne

Todd Thompson

Marc Jensen

Jeremy Frank

Maneesh Jain

Lester A Roberts

Methods for analyte detection with magnetic sensors are provided. Aspects of the methods include producing a magnetic sensor device having a magnetically labeled analyte from a sample, such as a serum sample, bound to a surface of a magnetic sensor thereof; and obtaining a signal, e.g., a real-time signal, from the magnetic sensor to determine whether the analyte is present in the sample. Also provided are devices, systems and kits that find use in practicing the methods of the invention. The methods, devices, systems and kits of the invention find use in a variety of different applications, including detection of biomarkers, such as disease markers.

Analyte detection with magnetic sensors

Magnetic nanoparticles and methods for their use in detecting biological molecules are disclosed. The magnetic nanoparticles can be attached to nucleic acid molecules, which are then captured by a complementary sequence attached to a detector, such as a spin valve detector or a magnetic tunnel junction detector. The detection of the bound magnetic nanoparticle can be achieved with high specificity and sensitivity.

Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules

Methods for evaluating motion of a cardiac tissue location, e.g., heart wall, are provided. In the subject methods, timing of a signal obtain from a strain gauge stably associated with the tissue location of interest is employed to evaluate movement of the cardiac tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.

Cardiac motion characterization by strain measurement

Implantable cardiac motion powered piezoelectric energy sources are provided. An aspects of embodiments of the subject implantable energy sources is that they include a piezoelectric transducer that converts cardiac mechanical energy to electrical energy. The subject energy sources find use in a variety of applications, including providing power to a wide range of implantable devices.

Implantable cardiac motion powered piezoelectric energy source

The invention includes devices and methods for forming random arrays of magnetic particles, arrays formed using these devices and methods, and to methods of using the arrays. The invention provides an assembly (chip) with magnetic domains that produce localized magnetic fields capable of immobilizing magnetic particles such as commercially available magnetic beads. Probe or sensor molecules can be coupled to the beads, which are then dispersed on the assembly, forming a random order array. The arrays can be used for analyzing samples, targets, and/or the interaction between samples and targets. The invention finds particular use in processes such as high-throughput genotyping and other nucleic acid hybridization-based assays.

Devices and methods to form a randomly ordered array of magnetic beads and uses thereof

The present invention provides a magnetic sifter that is small in scale, enables three-dimensional flow in a direction normal to the substrate, allows relatively higher capture rates and higher flow rates, and provides a relatively easy method of releasing captured biomolecules. The magnetic sifter includes at least one substrate. Each substrate contains a plurality of slits, each of which extends through the substrate. The sifter also includes a plurality of magnets attached to the bottom surface of the substrate. These magnets are located proximal to the openings of the slits. An electromagnetic source controls the magnitude and direction of magnetic field gradient generated by the magnets. Either one device may be used, or multiple devices may be used in series. In addition, the magnetic sifter may be used in connection with a detection chamber.

Magnetic sifter

Magnetic recording media comprising an ordered, ultra-high density array of 500 .ANG. diameter circular magnetic thin film islands on a substrate. The magnetic material supports magnetization perpendicular to the film plan, and each circular island comprises a single magnetic domain and a single information storage bit. An areal bit density of 10.sup.11 bits/in.sup.2 can be achieved by such an array. The magnetic array is generated using a single level mask comprised of a self-ordering polymer array, either an array of polymer spheres or a regular array of polymeric blocks in a phase-separating polymer film.

Growing community of inventors

Stanford, CA, United States of America

Robert L White