Smithkline Corporation

Sk&f Lab Co.

Other

Smithkline Beecham Corporation

Robert L Webb

Clifford S Labaw

George R Wellman

Joseph J Lewis

Neil Howard Baine

Clifton A Baile

Neville Lewis Holder

Carol Lynn McLaughlin

Gary Edward Zuber

Donald Nathaniel Klein

Wilford L Mendelson

Bing L Lam

Charles E Berkoff

Gregory Gallagher

Angelina J Duggan

Stella S Jones

Christine B Ogston

Roger Show

Antonietta R Mastrocola

Polymorph 'A' a novel polymorphic form of N-t-butyl-androst-3,5-diene-17.beta.-carboxamide-3-carboxylic acid. Novel processes for preparing polymorph 'A' are also disclosed.

'N-T-butyl-androst-3-5-diene-17 .beta.-carboxamide-3-carboxylic' acid

N-t-butyl-androst-3,5-diene-17.beta.-carboxamide-3-carboxylic acid

17-.alpha.-acyl steroids which inhibit 5-.alpha.-reductase

A method of preparing 2-cyanamidobenzimidazoles or 2-cyanamidobenzoxazoles comprising reacting N-cyanodiphenoxyiminocarbonate with an o-amino or o-hydroxy aniline.

Method for preparing 2-cyanamidobenzimidazoles or 2-cyanamidobenzoxazoles

Thiophenecarbonyl chloride is produced in good yields by the direct acylation of thiophene in the presence of aluminum chloride with control of temperature and concentration.

Preparation of 2-thiophenecarbonyl chloride

N-Phenyl-N'-cyano-O-phenylisoureas are prepared from N-cyanodiphenoxyimidocarbonate and an optionally substituted o-phenylenediamine or o-aminophenol. The isoureas are new chemical intermediates especially useful for preparing 2-cyanamido and 2-carbomethoxyaminobenzimidazole and benzoxazole compounds having anthelmintic activity.

N-Phenyl-N'-cyano-O-phenylisoureas

5-(5'-Halo-2'-methoxyphenyl)-3,4-dihalo-2(5H)-furanones are prepared by a Friedel-Crafts reaction using a p-haloanisole and a mucohalic acid in the presence of aluminum chloride. They are used as chemical intermediates for preparing hydroxyphenylpyridazinones.

Intermediates for preparing hydroxyphenylpyridazinones

A process for preparing 4-(oxy, thio or amino)methylimidazole compounds via displacement of the trisubstituted phosphonium group from 4-(trisubstituted phosphonium)methylimidazole compounds is disclosed.

Imidazolemethylphosphonium salts

A process for preparing 4-(oxy, thio or amino)methylimidazole compounds via displacement of the trisubstituted phosphonium group from 4-(trisubstituted phosphonium)-methylimidazole compounds is disclosed.

Process for preparing 4-substituted imidazole compounds

A new process and intermediates for preparing 2,3-dichloro-4-(2-thenoyl)phenoxyacetic acid (ticrynafen, a diuretic agent) using as a key reaction a Friedel-Crafts acylation of an esterified 3-(2,3-dichlorophenoxy)-1,2-propanediol using a thenoyl halide.

Use of cyclic esters to prepare 2,3-dichloro-4-(2-thenoyl)phenoxyacetic

New imidazolemethylphosphonium salts having a degradable group at the 2-position which are useful intermediates for preparing histamine H.sub.2 antagonists. This invention concerns the preparation of imidazolemethylphosphonium salts having no substituent at the 2-position by heating the compounds referred to above.

Process for preparing new imidazolemethylphosphonium salts

A custom grooming device has relatively opposing mirrors mounted on a base. A portable pistol-type hair dryer is mountable on the base; air from the dryer flows through a hose to an exhaust port located near one of the mirrors. The mirrors are adjustable in height and angle for viewing all parts of the head.

Combination mirror/hair dryer

New imidazolemethylphosphonium salts having a degradable group at the 2-position which are useful intermediates for preparing histamine H.sub.2 antagonists.

Intermediates and processes useful for preparing medicinal agents

A process for the production of magnesium oxide of moderate activity and high availability from a waste material containing dead-burned magnesium oxide of essentially no activity and lower availability (e.g., spent basic oxygen furnace firebrick) is disclosed. Spent basic oxygen furnace firebrick particles are calcined at a temperature of about 1000.degree. to about 2000.degree. F. for a time of from about 15 to about 60 minutes. The magnesium oxide in the spent, calcined firebrick is thus converted from dead-burned magnesium oxide to a magnesium oxide having a solubility of above about 90% in dilute hydrochloric acid and moderate activity in the nature of light-burned magnesium oxide. The color of the calcined magnesium oxide is also improved and the carbon content of the spent firebrick is essentially removed. The resulting product is generally useful in the same manner as conventional light-burned magnesium oxide.

Growing community of inventors

West Chester, PA, United States of America

Robert L Webb