Pfizer Corporation

Robert L Rosati

Kimberly O Cameron

Bruce A Lefker

Hua Zhu Ke

David D Thompson

Dennis J Hoover

Edward F Kleinman

Jasjit S Bindra

Ronald Thure Wester

Paul A Dasilva-Jardine

Yuhpyng Liang Chen

Spiros Liras

Martin Patrick Allen

Paul A DaSilva Jardine

Eric R Larson

James R Hauske

Wesley W Day

Andrew G Lee

Paul A Dasilva Jardine

Paul Da Silva-Jardine

Jasit S Bindra

The invention provides compounds of Formula I:  wherein R, R, R, R, R, R, Rand A are as defined. Compounds of formula I have activity inhibiting production of A&#x3b2;-peptide. The invention also provides pharmaceutical compositions and methods for treating diseases, for example Alzheimer's disease, in mammals comprising compounds of Formula I.

Pyrazole compounds for treatment of neurodegenerative disorders

This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disorders including osteoporosis.

Prostaglandin agonists

The invention provides compounds of Formula I: wherein R, R, R, R, R, R, R, and A are as defined. Compounds of formula I have activity inhibiting production of A&#x3b2;-peptide. The invention also provides pharmaceutical compositions and methods for treating diseases, for example Alzheimer's disease, in mammals comprising compounds of Formula I.

Compounds of this formulaare useful for treating or preventing, obesity, breast cancer, osteoporosis, endometriosis, cardiovascular disease and prostatic disease.

5-Substituted-6-cyclic-5,6,7,8-tetrahydronaphthalen 2-ol compounds which are useful for treating osteoporosis

Prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disorders including osteoporosis.

Prevention of loss and restoration of bone mass by certain prostaglandin agonists

The present invention provides methods of treating cancer of the liver, ovarian cancer, a desmoid tumor, glioma, pancreatic cancer, or renal cell carcinoma using an estrogen agonist/antagonist. The present invention also provides kits that contain an estrogen agonist/antagonist for treating cancer of the liver, ovarian cancer, a desmoid tumor, glioma, pancreatic cancer, or renal cell carcinoma.

Method of treating certain cancers using an estrogen agonist/antagonist

Benzothiophenes and related compounds as estrogen agonists

This invention relates to methods, pharmaceutical compositions and kits useful in treating conditions responsive to estrogen by the administration of estrogen agonists/antagonists. Conditions responsive to the compositions and methods include rheumatoid arthritis, colon cancer, tissue wounds, skin wrinkles and cataracts. The compositions are comprised of an estrogen agonist/antagonist and a pharmaceutically acceptable vehicle, carrier or diluent. The compositions and methods of treatment are effective while substantially reducing the concomitant liability of adverse effects associated with estrogen administration.

Compositions and methods for treating conditions responsive to estrogen

Prostaglandin agonists and their use to treat bone disorders

Estrogen agonists/antagonists

This invention relates to the use of EP2 receptor subtype selective prostaglandin E2 agonists to augment bone mass including the prevention and treatment of skeletal disorders in mammals, including humans.

Prevention and treatment of skeletal disorder with EP2 receptor subtype selective prostaglandin E2 agonists

Osteoporosis compounds

Prostaglandin agonists of formula (I), in which, for example, A is a sulphonyl or acyl group, B is N or CH, M contains a ring and K and Q are linking groups, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits useful for the treatment of bone disorders including osteoporosis.

Growing community of inventors

Mystic, CT, United States of America

Robert L Rosati