University of Pennsylvania

The United States Government As Represented by the Department of Veterans Affairs

Robert L Mauck

Hannah M Zlotnick

Daeyeon Lee

Bhavana Mohanraj

George R Dodge

Fuquan Tu

David Steinberg

Megan Farrell

Andrew Todd Clark

Xuemei Cheng

Brendan D Stoeckl

Liane Miller

Embodiments of the present invention relate to mechanically-activated microcapsules (MAMCs) for controlled drug-delivery, wherein the MAMCs release one or more active ingredients in response to mechanical stimuli in a subject's body. The MAMCs provide a platform for stimulating biological regeneration, biological repair, modifying disease, and/or controlling disease in mechanically-loaded musculoskeletal tissues.

Mechano-sensitive microcapsules for drug delivery

The present disclosure is concerned with magneto-patterned cell-laden hydrogel materials and methods of making and using those materials. The disclosed materials are useful for, among other things, repair of tissue defects, e.g., tissue at a tissue interface such as a bone-cartilage interface.

Magneto-patterned-cell-laden hydrogel materials and methods of making and using same

A method for forming a prosthesis comprising a bone-like portion and a cartilage-like portion can comprise additively manufacturing a first positive mold in accordance with a portion of a first three-dimensional model of a portion of a bone. A first negative mold can be formed from the first positive mold. The bone-like portion can be created within the first negative mold. A second positive mold of the bone and a cartilage can be additively manufactured from a second three-dimensional model. A portion of the second three-dimensional model can correspond to a portion of the first three-dimensional model. A second negative mold can be formed from the second positive mold. The bone-like portion can be positioned in the second negative mold so that the second negative mold and the bone-like portion can define a cartilage space that can be filled with a material to form the cartilage-like portion of the prosthesis.

Anatomic tissue-engineered osteochondral implant and method for fabrication thereof

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Philadelphia, PA, United States of America

Robert L Mauck