Neutrace, Inc.

Anumana, Inc.

Other

Neucures Inc.

University of Utah Research Foundation

Robert L Lux

Rohit Jain

Jay W Mason

Kappagantula Gopalakrishna Murty

Vijay Raghavan Dharmapuri Murali

A method for processing at least one electrical signal received from a mapping catheter electrode during cardiac mapping of a patient's heart is disclosed. The method comprises processing the at least one electrical signal to identify a heartbeat in the signal at a time t; analyzing a portion of the at least one electrical signal prior to the detected heartbeat to identify a time t' when motion of the mapping catheter electrode is at a minimum; and selecting a catheter position for the heartbeat as the position of the catheter at the time t′.

Removal of cardiac and respiratory motion from geometric points acquired from cardiac catheter electrodes

A method for quantifying a metric indicative of a condition of cardiac tissue in an electrogram is disclosed. The method includes detecting extrema in the electrogram, analyzing the detected extrema, selecting certain extrema based on a threshold and generating a fractionation metric including a count of the selected extrema.

Method and system for measuring electrogram fractionation

A method for calculating conduction velocity of a cardiac activation wavefront from electrophysiological ('EP') data points generated by a mapping system during a mapping procedure for a heart is provided. The method comprises for each EP data point comprising a local activation time, and position data defining a location within the heart corresponding to the local activation time: defining a neighborhood of EP points comprising the EP data point and a selection of neighboring EP data points; representing local activation time as a function f(x,y), where x and y our coordinates within a hyperplane defined to contain the neighborhood of EP data points based on the position data for each EP data point in the neighborhood; and calculating conduction velocity at the EP data point as a norm function of a gradient for the function f(x,y).

Method and system for calculating conduction velocity of a cardiac activation wavefront

A system and a method for determining cardiac tissue health based on a depolarization wave within an electrogram (EGM) is disclosed. The method comprises selecting a portion of the depolarization wave demarcated by a start time and end time and computing a Peak-to-Peak (P2P) voltage for the electrogram by computing a difference in voltages of the EGM corresponding to the start time and the end time.

Method and system for measuring cardiac electrogram depolarization voltage

A method for quantifying a metric indicative of a condition of cardiac tissue in an electrogram is disclosed. The method comprises detecting extrema in the electrogram, analyzing the detected extrema, selecting certain extrema based on a threshold and generating a fractionation metric comprising a count of the selected extrema.

Method and system for measuring unipolar and bipolar cardiac electrogram fractionation

A method for determining cardiac tissue health based on a depolarization wave within an EGM is disclosed. The method includes computing a first derivative with respect to time (DV/DT) of the EGM, determining extrema for the first derivative, establishing a value DV/DTbased on the extrema and mapping the value DV/DTto cardiac tissue.

Method and system for measuring cardiac tissue health based on DV/DTMIN of a depolarization wave within a cardiac electrogram

A method and system for determining QRS onset in cardiac signals is described. The system and method comprise acquiring N ECG signals and each comprises a plurality of QRS complexes. The system and method further selecting one QRS complex to form the basis of a search for the QRS onset point and defining a starting location within the ECG signal that has the selected QRS complex for the search. Further, the method and system comprises searching backwards in time from said starting location for a first nadir in the signal associated with the selected QRS complex and setting the time of the first nadir as the time for the QRS onset point.

Method and system for determining QRS onset in cardiac signals

Disclosed is a method for generating high resolution point cloud data for electro-anatomical mapping comprising receiving sparsely measured point cloud data having a plurality of data points. Surface mesh data comprising mesh points defining triangles on a myocardial surface is generated. The point cloud data is mapped to the surface mesh data. For each point of the surface mesh data that cannot be mapped to the point cloud data because there is a missing data point in point cloud data, an interpolation operation is performed based on the point cloud data within the neighbourhood of the point to generate a value for the missing data point. The interpolation operation is repeated N times. For every repetition, a difference between the value for the missing data point generated from the current iteration and the value for the missing data point generated from the immediately preceding iteration is compared, until the difference is below a threshold.

System and method for generating point cloud data for electro-anatomical mapping

Disclosed is a method for electro-anatomical mapping. In accordance with the method, surface mesh data is defined to represent the geometry of a myocardial surface. The mesh data comprises mesh points arranged to defined triangles on the myocardial surface and the mesh data is segmented into boundary areas. Point cloud data comprising a plurality of point cloud data points is received and each point cloud data point is assigned to a corresponding mesh point within a boundary area. The point cloud data point and its corresponding mesh point defines a mapping. For each mapping, a difference in a spatial location is determined between the points comprising the mapping. A warping function is selectively applied to spatially relocate the mesh point within each mapping based on the location of the corresponding point cloud data point within the mapping.

System and method for electro-anatomical mapping (EAM) based on a surface mesh

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A system for assessing a cardiac condition of a subject includes a sensor configured to record a plurality N of electrocardiographic signals from the subject to generate an ECG (electrocardiogram). The system further includes a processor configured to compute an RMS (root-mean-square) magnitude function from the recorded signals, and to measure from the RMS magnitude function an RMS variable that contains information about the cardiac condition of the subject. The ECG may be a standard 12-lead clinical ECG. The measured RMS variables may include RMS T-wave width, RMS RT recovery time, and RMS QT interval.

RMS electrocardiography system and method

Systems and methods are provided in the disclosure for estimating a risk of arrhythmia in a patient using electrocardiographic analysis. In certain aspects, a method of estimating a risk of arrhythmia in a patient is provided. The method comprises receiving electrocardiographic signals of the patient from a plurality of leads over a plurality of heart beats, averaging the electrocardiographic signals to produce an averaged electrocardiographic signal, and determining deflections in the averaged electrocardiographic signal, wherein each deflection has an amplitude and a duration. The method further comprises determining a significance of each deflection based on whether the amplitude of that deflection exceeds a threshold, and estimating a risk of arrhythmia in the patient based on at least one of a number, the amplitudes, and the durations of the significant deflections within a portion of the averaged electrocardiographic signal.

Growing community of inventors

Park City, UT, United States of America

Robert L Lux