Exxon Research and Engineering Company

Other

Oncbiomune, Inc.

Exxon Chemical Patents, Inc.

Exxon Research & Engineering

The Sallie Astor Burdine Breast Foundation

Robert L Elliott

Jonathan F Head

John B Gardiner

J Brooke Gardiner

Ramah Jessica Brod

Stanley J Brois

Kenneth Lewtas

Robert Dryden Tack

Won R Song

James Zielinski

Lawrence J Engel

Bryan D Hampton

Jean P Coquerel

Brooke Gardiner, Jr

Xianpeng Jiang

Brent M Segal

The present disclosure provides, among other things, methods for the treatment of neurodegenerative diseases (ND) and other mitochondrial disorders, and compositions related thereto. Described herein are in vitro (cell culture) and in vivo (animal model) experimental examples demonstrating mitochondrial organelle transplantation (MOT) for the treatment of NDs such as amyotrophic lateral sclerosis (ALS). Furthermore, as discussed herein, MOT has been performed in five human ALS patients with positive results—measurable improvement of their conditions has been observed, with no adverse events.

Compositions and methods for treatment of amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, and associated methods for preparing said compositions

A modular display and controller for providing information from user configurable display comprising a series of interconnected display modules. Users are able to physically attach and electrically attach arrayed rows of lighting elements together to form a variety of shaped signs for the display of scrolling information.

Modular display and controller

Compositions comprising a taxane or taxoid, such as paclitaxel, and a protein, such as albumin or a metal-transferrin, such as gallium-transferrin, can be prepared by combining an aqueous protein solution with a second solution containing the taxane or taxoid, a non-ionic surfactant, and an alcohol; adjusting the pH of the combined solutions to between about 7.9 and about 8.3; and purifying the pH-adjusted solution to remove solutes having a molecular weight less than 10,000 Da. Such compositions can be prepared that are substantially free of non-ionic surfactants, such as Cremophor EL, and are useful in the treatment of cancers, such as breast cancer.

Taxane- and taxoid-protein compositions

Pharmaceutical compositions useful as vaccines are described containing a purified surface or excreted protein qualitatively or quantitatively associated with a type of cancer, at least one interleukin (IL), and at least one colony stimulating factor (CSF), where the purified surface or excreted protein is provided in an amount sufficient to induce an immune response in an individual administered the composition. Such compositions can be used in methods for treating individuals having cancer, and for inducing an immunotherapeutic response in the same.

Immunotherapeutical method for treating cancer

Composition for a cancer vaccine

A cartridge seal is co-axially secured within the circular aperture of a back plate bolted to a pump housing. Annular recesses are provided around inner and outer sides of the back plate, surrounding the circular aperture. The cartridge-type seal includes a stationary gland assembly and a rotatable shaft collar assembly. The inner side of the gland assembly includes a taper bore surrounding the pump drive shaft, and a circumferential lip. The lip nests within the inner annular recess of the back plate. The outer side of the gland assembly includes a circumferential groove. The collar assembly is locked to the drive shaft by means of setscrews. A snap-ring within the circumferential groove of the gland assembly is located within the outer side recess of the back plate. The snap-ring precludes axial movement of the gland assembly, while allowing quick removal and replacement of the cartridge seal.

Cartridge-type mechanical seal and back plate

A breast cancer vaccine which comprises a mixture of tumor associated antigens (TAA) with low doses of recombinant interleukin-2 (IL-2) and granulocyte-macrophage colony stimulating factor (GM-CSF).

Vaccination of cancer patients using tumor-associated antigens mixed

The reaction cycle time for the copolymerization of unsaturated esters such as alkyl fumarates and vinyl acetate, and for the polymerization of methacrylates and acrylates may be dramatically reduced by carrying out the polymerization at elevated temperatures and pressures. An additional feature is the addition of initiator during polymerization which leads to improved products especially for lubricating oil pour depressants and fuel and crude oil flow improvers.

Copolymerisation of unsaturated esters

The invention concerns a lubricating oil containing less than 3 wt. % of a mixture of (1) a lubricating oil pour depressant and (2) a polyoxyalkylene ester, ether, ester/ether or mixture thereof containing one or more C.sub.10 to C.sub.30 alkyl groups and polyoxyalkylene glycol group of molecular weight 100 to 5000, the alkylene group of said polyoxyalkylene glycol containing from 1 to 4 carbon atoms. The pour depressant can for example be a vinyl acetate copolymer, a polyalkylacrylate, a polyalkylmethacrylate or an esterified olefin/maleic anhydride copolymer.

Lubricating oil composition

A liquid end for a reciprocating pump having easily removable valves and valve retainers in which the liquid end has a cylindrical valve chamber communicating with the fluid inlet and fluid outlet and the pump cylinder, the chamber having increased internal diameter portions so that the internal diameter of each portion is slightly larger than the portion just below it, the intake valve being received on an internal ledge, and intake valve retainer engaging and holding the intake valve in position and having a cylindrical ceiling surface engaging a portion of a wall of the valve chamber, an exhaust valve supported on top of the intake valve retainer and exhaust valve retainer engaging the exhaust valve and holding it in place, the exhaust valve retainer having a circumferential cylindrical portion sealably engaging a portion of the valve chamber so that the valves may be removed by removing the chamber and each chamber may be removed by a short upward pull, each retainer, upon upward pull, immediately passing into an area of the valve chamber having an increased internal diameter. Intake and exhaust valves are identical in size. Valve seats and valve discs are fully reversible, providing two useful wear surfaces, instead of one. Fast, convenient removal is provided by the construction.

Liquid end for a reciprocating pump having easily removable valves and

A lubricating oil composition comprising a major amount of lubricating oil and a viscosity index improving amount of an oil-soluble polymer composition comprising an ethylene copolymer, preferably an oxidatively and mechanically degraded ethylene copolymer, having an ethylene content of 26-79 weight percent (35-85 mole percent), a C.sub.3 to C.sub.18 higher alpha-olefin and from about 1-25 weight percent of an alkyl norbornene having from about 8 to 28 carbons, preferably ethyl norbornene and preferably at least a pour point depressing amount of a lubricating oil pour point depressant, e.g. an alkyl fumarate vinyl acetate copolymer, whereby superior low temperature viscometrics is provided to said lubricating oil composition.

Oil compositions containing oil-soluble, oxidatively and mechanically

An ene adduct and adduct derivatives of a C.sub.3 -C.sub.24 ethylenically unsaturated nitrogen-containing reactant, e.g. acrylonitrile, and a copolymer of ethylene, at least one C.sub.3 to C.sub.50 alpha-monoolefin and at least one non-conjugated diene, said adduct containing from about 0.005 to 7% by weight nitrogen and having a number average molecular weight of from about 1000 to 500,000, in oil-soluble form have utility as a multi-functional V.I. improver for lubricating oils.

Ethylene copolymer/ethylenically unsaturated nitrogen reactant ene

Oil-soluble, derivatized ethylene copolymers derived from about 2 to 98 wt. % ethylene, and one or more C.sub.3 to C.sub.28 alpha-olefins, e.g. propylene, which are grafted, preferably solution-grafted under an inert atmosphere and at elevated temperatures and in the presence of a high-temperature decomposable free-radical initiator, with an ethylenically-unsaturated carboxylic acid material and thereafter reacted with a polyfunctional material reactive with carboxy groups; such as (a) a polyamine, or (b) a polyol, or (c) a hydroxy amine, or mixtures thereof to form carboxyl-grafted polymeric derivatives are reacted with oil-soluble hydrocarbyl substituted acids, preferably with long chain alkyl aryl sulfonic acids with an average side chain carbon number of about 20-40, to yield haze-free hydrocarbon solutions, e.g. a lubricant additives composition, of increased dispersant potency. Useful number average molecular weight (M.sub.n) of said copolymers range from about 700 to 500,000, however, if the molecular weight is from 10,000 to 500,000 then these copolymers are also useful as multifunctional viscosity index improvers.

Polymeric additives for fuels and lubricants

Multipurpose lubricating oil additives having utility as viscosity index improvers, antiwear agents, sludge dispersants and pour point depressants comprise oil-soluble reaction products of (1) nitrogen compounds having one or more amino groups and/or (2) oxygen compounds having one or more hydroxyl, epoxide or ether groups and/or (3) sulfurizing agent and/or boron compound and/or phosphorous compound with an electrophilically terminated anion of an oxidized copolymer of ethylene and at least one C.sub.3 -C.sub.50 alpha monoolefin.

Multipurpose lubricating oil additive based on electrophilically

Oil-soluble, derivatized ethylene copolymers derived from about 2 to 98 wt. % ethylene, and one or more C.sub.3 to C.sub.28 alpha-olefins, e.g. propylene, which are grafted, preferably solution-grafted under an inert atmosphere and at elevated temperatures and in the presence of a high-temperature decomposable free-radical initiator, with an ethylenically-unsaturated dicarboxylic acid material and thereafter reacted with a polyamine having at least two primary amine groups, e.g. an alkylene polyamine such as diethylene triamine, to form carboxyl-grafted polymeric imide, usually maleimide, derivatives are reacted with an anhydride of a C.sub.1 -C.sub.30 hydrocarbyl substituted acid, preferably acetic anhydride, to yield an oil-soluble stable amide of said polyamine whereby oil solutions of said amide derivative are characterized by minimal viscosity change over an extended period of time. Useful number average molecular weight (M.sub.n) of said copolymers range from about 700 to 500,000; however, if the molecular weight is from 10,000 to 500,000 then these copolymers are also useful as multifunctional viscosity index improvers.

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Scotch Plains, NJ, United States of America

Robert L Elliott