Armour Pharmaceutical Company

Rhone-poulenc Rorer Pharmaceuticals Inc.

Rorer Pharmaceutical Corporation

Armour and Company

Robert L Colescott

Ronald C Orlowski

Glenn L Stahl

Emil Kaiser

Charles D Bossinger

Jay K Seyler

Geoffrey W Tregear

Paul I Cook

Takashi Enkoji

Everett Flanigan

James E Geever

New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a histidine in position 17. The position 17 histidine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.

Des-17-histidine-calcitonin

New peptides are disclosed which have biological activity of the same type as known calcitonins and which have an alanine in position 19 instead of the natural leucine or phenylalanine found in those positions. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.

(19-Alanine) calcitonin

New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a disulfide bond connecting the cysteines at positions one and seven. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin partially protected peptides.

(Bis-1,7-S-acetamidomethyl-L-cysteine)salmon calcitonin

New peptides are disclosed which have biological activity of the same type as known calcitonins and which have an alanine in positions 16 and 19 instead of the natural leucine or phenylalanine found in those positions. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.

[16,19-Di-alanine] calcitonin

New peptides are disclosed which have biological activity of the same type as known calcitonins and which have an alanine in position 16 instead of the natural leucine or phenylalanine found in that position. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.

[16-Alanine]calcitonin

Resin peptides useful in the preparation of peptides having biological activity, and particularly such resin peptides containing Pro--Asp--CH.sub.2 --  or Pro--Asn--CH.sub.2 --  at one end of an amino acid chain,  being the resin and Pro, Asp and Asn being the residues of the amino acids proline, aspartic acid and asparagine; and processes for the preparation of such resin peptides.

Synthesis of peptides

Resin peptides useful in preparing peptides having biological activity, and particularly such resin peptides containing ALA-GLU-CH.sub.2 - R at one end of an amino acid chain, R being the resin and ALA and GLU being the residues of the amino acids alanine and glutamic acid; and processes for the preparation of such resin peptides. Resin peptides including ACTH.sup.1-28 are disclosed which have adrenocorticotropic activity along with processes for their preparation.

Resin peptides useful in the preparation of peptides having biological activity, and particularly such resin peptides containing R--CH.sub.2 --O--Phe--Asn at one end of an amino acid chain, R being the resin and Phe and Asn being the residues of the amino acids phenylalanine and asparagine; and processes for the preparation of such resin peptides. Resin peptides are disclosed which contain amino acid chains identical with the amino acid chains of natural peptides having biological activity. Other resin peptides are disclosed which contain amino acid chains in which the amino acid residues differ in kind and sequence from amino acid chains of natural biologically active peptides but from which peptides having biological acitivity may be derived.

Synthesis of peptides with parathyroid hormone activity

Resin peptides useful in the preparation of peptides having biological activity, and particularly such resin peptides containing R-CH.sub.2 -Phe-Glu at one end of an amino acid chain, R being the resin and Phe and Glu being the residues of the amino acids phenylalanine and glutamic acid; and processes for the preparation of such resin peptides. Resin peptides are disclosed which contain amino acid chains identical with the amino acid chains of natural peptides having biological activity. Other resin peptides are disclosed which contain amino acid chains in which the amino acid residues differ in kind and sequence from amino acid chains of natural biologically active peptides but from which peptides having biological activity may be derived.

Growing community of inventors

Bourbonnais, IL, United States of America

Robert L Colescott