Hewlett-packard Development Company, L.p.

Life Technologies Corporation

Robert L Cobene

John Phillip Ertel

Akinobu Kuramoto

Steven W Trovinger

John Dixon

Ian Walton

Achim Karger

Alexander V Dukhovny

Raymond G Schuder

Dan Kline

Adam Sannicandro

Ross R Allen

Jeffrey M DiCarlo

Michael Simon

Alexander Khorlin

Glen Eric Montgomery

In one aspect, a biological sequencing device comprising a cartridge configured to be removed from the instrument is disclosed. In various embodiments the cartridge can include one or more capillaries suitable for capillary electrophoresis, a reservoir and a pump. In various embodiments the reservoir can contain a separation matrix. In various embodiments the pump can load a capillary with separation matrix. In another aspect the biological sequencing device can include one or more capillaries and an integrated valve assembly. In various embodiments the integrated valve assembly can provide a polymer to the one or more capillaries.

Apparatuses, systems and methods for sequencing using capillary electrophoresis

The present disclosure relates, in some embodiments, to an apparatus for conducting a capillary electrophoresis assay. The apparatus can comprise a capillary array comprising an anode end and a cathode end, the capillary array provided in a housing further comprising a reservoir configured to house a separation medium and an anode buffer. The system can also comprise an injection mechanism configured to deliver sample to the cathode end of the capillary array, and a temperature control zone, wherein the temperature control zone is configured to control the temperature of the interior of the housing.

Capillary array cartridge for capillary electrophoresis systems

Systems and methods for attaching a cover to a text body to create bound documents with floating and attached spines are described. In some embodiments, a solid pressure sensitive adhesive film is applied between a cover and the side hinge areas of a text body, and a cover is bound to the side hinge areas of the text body with pressure. A solid pressure sensitive adhesive tape may be dispensed from an adhesive dispenser that includes a plug-in cartridge housing, a supply spool, and a take-up spool. In other embodiments, an adhesive sheet that includes a hot melt adhesive film and a backing is applied to the text body, with the hot melt adhesive film in contact with the side hinge areas and the spine of the text body. The hot melt adhesive is exposed in areas corresponding to the side hinge areas of the text body for attaching the cover to the text body. In one embodiment, an adhesive sheet includes a hot melt adhesive film and a backing layer that is attached to the hot melt adhesive film and has one or more slits extending in a substantially longitudinal direction. The slitted backing layer is configured to expose the hot melt adhesive upon stretching of the backing layer in a direction substantially orthogonal to the longitudinal direction.

Systems and methods of attaching a cover to a text body

A computer implemented method for utilizing a plurality of self-activating display shaping devices to provide shape adjustment information for a digital image projected on a display is disclosed. In one embodiment, the plurality of display shaping devices are automatically activated, the plurality of display shaping devices defining a desired digital image shape for a display. In addition, the plurality of display shaping devices is utilized to identify an actual projected digital image shape. The actual projected digital image shape is then compared with the desired digital image shape for the display. Correction information is then provided for adjusting the actual projected digital image shape to approximate the desired digital image shape for the display.

Plurality of self-activating display shaping devices defining a display area

Systems and methods for registering a cover with respect to a text body to create bound documents with floating and attached spines are described. In one embodiment, a text body having a front end, two opposed side ends, and a spine end that is located opposite to the front end is formed from two or more sheets, and a single-piece cover is registered with respect to at least one end of the text body.

Systems and methods of registering a cover with respect to a text body

Systems and methods of binding sheets by activating a microencapsulated binding agent are described. Each sheet to be bound has an exposed binding surface region near a spine edge. A frontside adhesive system is disposed over the frontside binding surface region and comprises a binding agent that is encapsulated in a plurality of microcapsules. The adhesive system is non-tacky to enable the sheets to be stacked and individually processed until the binding agent is released from the microcapsules.

Binding sheets by activating a microencapsulated binding agent

Systems and methods of dispensing adhesive in a bookbinding system are described. Sheets may be bound into bound text bodies having respective spines exposed for adhesive application and characterized by multiple length dimensions and multiple thickness dimensions. In one aspect, a sheet binding system comprises an adhesive dispenser that is configured to dispense across the thickness dimension of a text body spine solid sheet adhesive having one of multiple effective widths that is sized to correspond substantially to the length dimension of the text body spine. In accordance with this approach, books of different lengths (or heights) may be readily bound with solid sheet adhesive that may be contained within a single, replaceable cartridge housing.

Dispensing adhesive in a bookbinding system

Systems and methods of determining when adhesive in a replaceable adhesive dispenser is nearly spent are described. In one aspect, a bookbinding system includes a receptacle for receiving a plug-in cartridge housing of an adhesive dispenser that contains a length of solid sheet adhesive wound into a roll, and an adhesive quantity interrogator that is configured to obtain an indication of the length of solid sheet adhesive remaining within the plug-in cartridge housing. In another aspect, an adhesive dispenser includes a plug-in cartridge housing that is configured to plug into a receptacle of a bookbinding system, a length of solid sheet adhesive that is disposed within the plug-in cartridge housing and wound into a roll, and an indicator of the length of solid sheet adhesive remaining within the plug-in cartridge housing.

Determining when adhesive in a replaceable adhesive dispenser is nearly spent

Systems and methods of managing consumables used in a bookbinding system are described. In one aspect, a bookbinding consumables quantity interrogator is configured to obtain information relating to usage of one or more consumables in a bookbinding system, and a processor is configured to compute usage statistics for the one or more bookbinding consumables based upon usage information obtained by the bookbinding consumables quantity interrogator.

Growing community of inventors

Palo Alto, CA, United States of America

Robert L Cobene