Kosan Biosciences Incorporated

Robert L Arslanian

John R Carney

Brian Walter Metcalf

Gary W Ashley

Li Tang

Peter J Licari

Lawrence Cadapan

Recombinanthost cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.

Production of polyketides

Methods are provided for purification of epothilone D and epothilone D analogs from epothilone producing cells such as, for example,and(recombinant). Epothilone can be purified from fermentation broth, for example by using resins, chromatography, and crystallization. Epothilone D can be crystallized from a binary solvent system in which water is the forcing solvent.

Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate

This invention relates to compounds of formula (I)and to pharmaceutically acceptable salts and solvates thereof, wherein R, R, R, R, R, W, X, Y, and Ar are as defined herein. Compounds of formula (I) are useful in the treatment of diseases or conditions characterized by cellular hyperproliferation. This invention also relates to means for the preparation of compounds of formula (I); formulations containing compounds of formula (I); and methods for the use of said compounds and formulations in the treatment of a disease or condition characterized by cellular hyperproliferation, including cancer.

Epothilone derivatives and methods for making and using the same

Epothilone compounds and methods for making and using the same

Fermentation based methods for producing mycolactones allows one to produce large quantities of mycolactones, which can be purified by extraction and chromatography to yield pure preparations of mycolactones A, B, C, and D.

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Pacifica, CA, United States of America

Robert L Arslanian