Rohm and Haas Company

Robert L Albright

Eric C Peters

Larry W Steffier

Eric G Isacoff

Jon R Fisher

A bile acid sequestrant having a crosslinked polymeric matrix and having branches supported on the polymeric matrix and providing bonding sites for binding bile acid conjugates to the sequestrant, pharmaceutical compositions containing the sequestrant for treatment of elevated plasma cholesterol level are described.

Bile acid sequestrant

A nontoxic polymer comprising a backbone having a pendant groups which have sites which are capable of forming ionic bonds and sites capable of forming hydrogen bonds with respective receptive sites on the anions of conjugate acids formed by the reaction of bile acids with glycine and of bile acids with taurine, preferred polymers including polymeric amides, and pharmaceutical compositions containing the same for treatment of hypercholesterolemia.

Composition and method for controlling cholesterol

Treatment of water-soluble, amine-containing polymers with strong acid, cation exchange resins from aromatic copolymer crosslinked with 2-25% polyvinyl crosslinker, followed by ultrafiltration with a membrane filter having a molecular-weight cutoff, measured against the polymers to be treated, of about 10,000 to about 15,000, results in a highly effective removal of residual monomers and oligomers of less than 500 molecular weight.

Process for removing residual monomers and oligemers from

Anion exchange resin derived from insoluble crosslinked polymers of vinyl benzyl chloride which are prepared by polymerizing vinyl benzyl chloride and a crosslinking monomer are particularly suitable in the treatment of uranium bearing leach liquors.

Growing community of inventors

Churchville, PA, United States of America

Robert L Albright