Signal Pharmaceuticals, Inc.

Biological Dynamics, Inc.

Xzom, Inc.

Robert Kovelman

Robert Paul Turner

Rajaram Krishnan

Juan Pablo Hinestrosa Salazar

Miguel S Barbosa

James Gregory Madsen

David Joseph Searson

David Y Liu

Iryna Clark

Graham K Bilter

The present invention includes methods, devices and systems for isolating, identifying, analyzing, and quantifying biological materials from fluid samples. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity biological materials from complex fluids such as blood, serum, or plasma.

Methods and devices for detection of multiple analytes from a biological sample

Systems, devices, media, methods, and kits are disclosed to integrate and exchange information of analyte analysis kits. Analyte analysis can be performed and presented using in association with advertising or questions.

Methods and systems for analyte information processing

Reporter systems for assaying positive sense RNA virus replication are provided. The reporter systems comprise a reporter gene in antisense orientation, flanked by the complements of 5&prime; and 3&prime; viral genome ends, such that exposure to an RNA-dependent RNA polymerase results in the generation of mRNA encoding an active reporter protein. Such systems may be used, for example, to detect active RNA virus and to monitor RNA virus therapies.

Antisense reporter system for assaying RNA virus replication

Plasmid reporter systems for assaying transcription and replication are provided. The plasmids comprise dual reporters for use in the independent evaluation of transcription and replication. Such plasmids may be used for example, for determining the role of endogenous factors in transcription and replication and for evaluating the effect of exogenous modulators on such processes. Within certain embodiments, the plasmids comprise (a) a first reporter gene operably linked to a promoter and a binding site for human papillomavirus E1 and/or E2 protein; (b) a second reporter gene that is linked to a promoter that is not substantially modulated by E1 and/or E2 and (c) an origin of replication bound by human papillomavirus E1 protein.

Dual reporter system and methods of use therefor

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La Jolla, CA, United States of America

Robert Kovelman