Edwards Lifesciences Corporation

Plasmaselect Gmbh Teterow

Reinke, Petra

Baumann, Gert

Felix, Stephan

Brehme, Stefan

Robert Koll

Reiner Spaethe

Petra Reinke

Gert Baumann

Wolfgang Bohm

Jutta Muller-Derlich

Franz A Bieber

Jutta Müller-Derlich

Stephan Felix

Stefan Brehme

Immunoapheresis treatment for cardiomyopathy comprises passing the patient's plasma over a column having coupled thereto a specific ligand for human immunoglobulin, thereby removing a significant portion of the immunoglobulin from the patient's plasma, and then reinfusing the plasma to the patient. The invention is the use of a specific ligand for human immunoglobulin in the manufacture of a column having the ligand coupled thereto, the column being useful for immunoapheresis treatment of a patient with cardiomyopathy. The specific ligand binds, and thereby removes, human autoantibodies which are harmful to cardiac tissue such as antibodies against &#x3b2;-adrenergic receptors, ADP-ATP carriers, &#x3b1; and &#x3b2; myosin heavy chains, and adenine nucleotide translocators. Immunoapheresis treatment using the column results in improvement of hemodynamic parameters such as mean arterial pressure, mean pulmonary pressure, pumonary capillary wedge pressure, right atrial pressure, cardiac output, cariac index, stroke volume index, and systemic vascular resistance.

treatment of cardiomyopathy by removal of autoantibodies

The invention provides a method to prevent or ameliorate hyperacute or acute rejection of a human donor organ transplanted to a human recipient. Hyperacute rejection would normally occur after a human subject receives a transplanted human organ against which the subject has preformed anti-HLA antibodies. Acute rejection occurs when the recipient of a human organ forms antibodies against that organ after transplant. The invention method comprises passing the plasma of the recipient over a sterile and pyrogen-free column coupled to anti-human immunoglobulin antibodies which bind to and remove a significant portion of the immunoglobulin from the subject's plasma.

Ameliorating immunological rejection of allograft

Growing community of inventors

Kirchheim, Germany

Robert Koll