Princeton University

Vorbeck Materials Corporation

Other

Rutgers, the State University of New Jersey

Halliburton Energy Services, Inc.

Dow Global Technolgoies LLC

North Carolina State University

University of Connecticut

Celator Pharmaceuticals, Inc.

Robert K Prud'homme

Ilhan A Aksay

Sibel Korkut

Douglas H Adamson

John S Lettow

John M Crain

Chuan-Hua Chen

Katherine S Chiang

Robert F Pagels

Ahmed Abdala

Saad A Khan

Robert M Kelly

Pascal Leduc

Akash Tayal

David L Milius

Chester E Markwalter

Marian Gindy

Ying Liu

Richard A Register

Brian K Johnson

Bulent Ozbas

Nathalie M Pinkerton

Margarita Herrera-Alonso

Mustafa Erhan Yildiz

Nikolas T Weissmueller

Shuyang Pan

Lei Shi

Donald L Schmidt

Kathryn Elizabeth Uhrich

Ian D Robb

Lewis R Norman

Lawrence D Mayer

Gene D Rose

Howard A Stone

Henry A Pfeffer

Patrick J Sinko

Mathieu Joanicot

Michael J McAllister

Christine Allen

Patrick B Smith

Prabhas V Moghe

David M Meunier

Joel Marcel Coret

Gordon D McCann

Regan Crooks

Kurt D Ristroph

Iihan A Aksay

Brooks Powell

Rajeev Garg

Sherif Ibrahim

Walid S Saad

Leon Wang

Scott A Baker

Rodney D Priestley

Paradorn Rummaneethorn

Hoang D Lu

Victoria Lee

Adam W York

Jiandi Wan

Christopher O'Neil

Henry S Ashbaugh

Michael Stredney

Dayuan Gao

Wan Y Shih

Wei H Shih

Xiaoping Li

James S Vartuli

Catherine-Ann Cukras

Christine J Allen

Rui Liu

Paul A Burke

Chang Tian

Nicholas Caggiano

Chris Sosa

Marian E Gindy

David J Mathre

Varun Kumar

From diagnostic imaging to drug delivery, nanoparticles have found a tremendous variety of uses across fields. Often, when designing these nanoscale constructs, the two most important criteria are particle size and core loading. For example, small particles below 100 nm can have many advantages for drug delivery—including improved specificity to tumors through the enhanced permeability and retention (EPR) effect. Likewise, higher loading nanoparticles translate very well to more effective drug delivery and cancer imaging—allowing for lower dosage and reduced costs. Traditional formulations of nanoparticles using drug absorption or precipitation methods generally struggle to obtain >50% loading. Disclosed herein is a precipitation process allowing for production of stable particles at very high core loading by taking advantage of different time scales while maintaining biologically relevant sizes. New mixing designs allow for the separation of the precipitation and stabilization steps to generate these high loading nanoparticles.

Sequential multi-step flash nanoprecipitation for the formation of nanoparticles with high core loadings

Methods for encapsulating water-soluble biologic and small molecule active pharmaceutical ingredients (APIs) into nanoparticles by applying nanoprecipitation techniques and ion-pairing the nanoparticles with hydrophobic counterions to produce new API salts that exhibit altered solubilities are presented.

Hydrophobic ion pairing and flash nanoprecipitation for formation of controlled-release nanocarrier formulations

Hydrophilic molecules such as biologics, which can include peptides, proteins, and other biologically-derived materials, can be used as therapeutic agents in medical applications. They can face administration challenges because of poor membrane permeability and rapid clearance from the blood stream. Methods for the formation of a core-shell-brush nanoparticle from an A-B-C triblock copolymer are set forth. A hydrophilic core can contain the biologic and the C Block of the copolymer. The shell can be comprised of the precipitated B Block, and the A Block can form a stabilizing brush layer. The particles can be assembled by sequential precipitations under defined mixing conditions. Presented herein are methods to tune release based on process parameters during particle assembly and triblock characteristics.

Triblock copolymer stabilizers for the formation of nanoparticles encapsulating soluble biologics, therapeutics, and imaging agents

In one aspect, methods of preparing composite nanoparticle compositions are described herein. For example, in some embodiments, a method comprises providing a zein solution stream, an organic fluid stream including at least one additive and at least one buffer fluid stream. The zein solution stream, organic fluid stream and buffer fluid stream are delivered to a chamber for mixing at one or more rates sufficient to flash precipitate composite nanoparticles including the additive encapsulated by a shell comprising the zein.

Nano-encapsulation using GRAS materials and applications thereof

A method for controlling the encapsulation efficiency and burst release of water soluble molecules from nanoparticle and microparticle formulations produced by the inverted Flash NanoPrecipitation (iFNP) process and subsequent processing steps is presented. The processing steps and materials used can be adjusted to tune the encapsulation efficiency and burst release of the encapsulated water-soluble material. The encapsulation efficiency of the soluble agent in the particles and the burst release of the soluble agent from the particles can be controlled by: (1) the copolymers used in the assembly or coating process, (2) the degree of crosslinking of the nanoparticle core, (3) the incorporation of small molecule or polymeric additives, and/or (4) the processing and release conditions employed.

Method for controlling encapsulation efficiency and burst release of water soluble molecules from nanoparticles and microparticles produced by inverse flash nanoprecipitation

An 'inverse' precipitation route to precipitate aqueous soluble species with copolymers as nanoparticles having a hydrophilic, polar core and a less polar shell is described.

Process for encapsulating soluble biologics, therapeutics, and imaging agents

The invention described herein relates to sterically stabilized colloidal constructs comprising preformed colloidal particles encapsulated within a polymeric shell. The constructs, which are controllably sized, are nanoparticles comprising hydrophobic elements, electrostatically charged particles with hydrophobic surfaces, hydrophobic inorganic nanostructures, and amphiphilic copolymers with hydrophobic domains and hydrophilic domains. The constructs are made by a process that allows for the simultaneous encapsulation of a preformed colloidal agent as well as a dissolved hydrophobic active within the core of the polymeric nanoparticle. Among the actives incorporated in various embodiments are organic fluorescent dyes, metal nanostructures and superparamagnetic materials for use in combined fluorescence, optical and magnetic resonance imaging applications, and hydrophobic drugs for therapeutic applications.

Composite flash-precipitated nanoparticles

Hybrid polymer-inorganic nanocolloids and methods of making them are described.

Hybrid polymer-inorganic nanocolloids and methods of making them

An 'inverse' precipitation route to precipitate aqueous soluble species with copolymers as nanoparticles having a hydrophilic, polar core and a less polar shell is described. The aggregation of these nanoparticles to form larger microparticles and monoliths provides a highly loaded construct (e.g., a depot) for the sustained and controlled release of actives.

Particulate constructs stabilized by amphiphilic copolymers and comprising at least one active coupled to a hydrophobic moiety provide sustained release of the active in both in vitro and in vivo environments.

Particulate constructs for release of active agents

Printed electronic device comprising a substrate onto at least one surface of which has been applied a layer of an electrically conductive ink comprising functionalized graphene sheets and at least one binder. A method of preparing printed electronic devices is further disclosed.

Printed electronics

A thermal overload device containing a polymer composite, which contains at least one polymer and a modified graphite oxide material, containing thermally exfoliated graphite oxide having a surface area of from about 300 m/g to 2600 m/g, and a method of making the same.

Thermal overload device containing a polymer composition containing thermally exfoliated graphite oxide and method of making the same

The present invention relates to nanoparticle compositions and treatment of cardiovascular disease using nanoparticles to target Class A and B scavenger receptors. This invention further relates to methods of detecting cells that express scavenger receptors, detecting atherosclerotic lesions, and targeting bioactive amphiphilic macromolecules to cells that express scavenger receptors.

Bioactive amphiphilic polymer stabilized nanoparticles with enhanced stability and activity

Growing community of inventors

Lawrenceville, NJ, United States of America

Robert K Prud'homme