May & Baker, Ltd.

Robert K Chambers

Keith A Stuttle

David J Lythgoe

Garry Fenton

Neil Victor Harris

Christopher Smith

Barbara Joyce Broughton

Michael J Ashton

David Riddell

Ian Michael McFarlane

Edward Lunt

Libert C Saunders

Andrew W Bridge

Christopher G Newton

Donald I Dron

Peter J Warne

David W Gilmour

Adnan H Al-Shaar

Diane M Kelsey

Ian McClenaghan

Peter Lowden

Duncan C McDougall

Malcolm P Toft

Therapeutically useful isoquinolinone derivatives of the formula A--X--R.sup.3, wherein A represents a group of the formula: ##STR1## wherein R.sup.1 and R.sup.2 represents cycloalkyl, alkyl, alkenyl or alkynyl optionally substituted by halogen or cycloalkyl, or represents optionally substituted aryl or heteroaryl, R.sup.4 represents hydrogen, halogen, optionally substituted alkyl, alkenyl or alkynyl, optionally substituted aryl or heteroaryl, or a group R.sup.6 O-- wherein R.sup.6 represents alkyl, aryl or arylalkyl, X represents ethylene or vinylene, R.sup.3 represents a group of the formula:

Isoquinolinones

Ethene derivatives

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Little Waltham, United Kingdom

Robert K Chambers