Janssen Pharmaceutica Nv

Robert Jozef Maria Hendrickx

Jan Heeres

Lieven Meerpoel

Ludwig Paul Cooymans

Gustaaf Maria Boeckx

Christopher John Love

Erwin Coesemans

Peter Jacobus Johannes Antonius Buijnsters

Guy Rosalia Eugeen Van Lommen

Jean-Pierre André Marc Bongartz

Julien Georges Pierre-Olivier Doyon

Marcel Jozef Maria Van Der Aa

Nele Vandermaesen

Julien Georgespierre-Olivier Doyon

This invention concerns the use of a compound of formula (I') a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z is halo; Calkyl; Calkylcarbonyl; Calkyloxycarbonyl; aminocarbonyl; Calkyl substituted with hydroxy, carboxyl, cyano, amino, amino substituted with piperidinyl, amino substituted with Calkyl substituted piperidinyl, mono- or di(Calkyl)amino, aminocarbonyl, mono- or di(Calkyl)aminocarbonyl, Calkyloxycarbonyl, Calkyloxy, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl; polyhaloCalkyl; cyano; amino; mono- or di(Calkyl)aminocarbonyl; Calkyloxycarbonyl; Calkylcarbonyloxy; aminoS(&#x2550;O)&#x2014;; mono- or di(Calkyl)aminoS(&#x2550;O); &#x2014;C(&#x2550;N&#x2014;R)NRR; Q is optionally substituted Ccycloalkyl, phenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, benzthiazolyl, benzoxazolyl, benzimidazolyl, indazolyl, or imidazopyridyl, or Q is a radical of formula L is optionally substituted phenyl or an optionally substituted monocyclic 5 or 6-membered partially saturated or aromatic heterocycle or a bicyclic partially saturated or aromatic heterocycle; aryl is optionally substituted phenyl; for the manufacture of a medicament for the prevention or the treatment of inflammatory and/or auto-immune diseases mediated through TNF-&#x3b1; and/or IL-12.

2-amino-4,5-trisubstituted thiazolyl derivatives

This invention concerns the use of a compound of formula (I'), a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z is halo; Calkyl; Calkylcarbonyl; Calkyloxy -carbonyl; aminocarbonyl; Calkyl substituted with hydroxy, carboxyl, cyano, amino, amino substituted with piperidinyl, amino substituted with Calkyl substituted piperidinyl, mono- or di(Calkyl)amino, aminocarbonyl, mono- or di(Calkyl)aminocarbonyl, Calkyloxycarbonyl, Calkyloxy, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl; polyhaloCalkyl; cyano; amino; mono- or di(Calkyl)aminocarbonyl; Calkyloxycarbonyl; Calkylcarbonyloxy; aminoS(&#x2550;O)&#x2014;; mono- or di(Calkyl)aminoS(&#x2550;O); &#x2014;C(&#x2550;N&#x2014;R)NRR; Q is optionally substituted Ccycloalkyl, phenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, benzthiazolyl, benzoxazolyl, benzimidazolyl, indazolyl, or imidazopyridyl, or Q is a radical of formula (b-1), (b-2), or (b-3), L is optionally substituted phenyl or an optionally substituted monocyclic 5 or 6-membered partially saturated or aromatic heterocycle or a bicyclic partially saturated or aromatic heterocycle; aryl is optionally substituted phenyl; for the manufacture of a medicament for the prevention or the treatment of inflammatory and/or auto-immune diseases mediated through TNF-&#x3b1; and/or IL-12 

Amino acid ester containing azole antifungals

The present invention concerns novel compounds of formula

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Beerse, Belgium

Robert Jozef Maria Hendrickx