Darwin Discovery Limited

Chiroscience, Ltd.

Celltech R&d Limited

Robert John Watson

Andrew Douglas Baxter

David Alan Owen

John Gary Montana

John Fraser Keily

Hazel Joan Dyke

Duncan Robert Hannah

Duncan Batty

Alan Findlay Haughan

Andrew Sharpe

Verity Margaret Sabin

Richard John Davenport

Steven Colin Beasley

Neil Phillipson

Compounds of the general formula (I)are described wherein Rand R, which may be the same or different, is each a hydrogen atom or a CF, CFH or CFHgroup, provided that when one of Rand Ris a hydrogen atom, then the other is a CF, CFH or CFHgroup, and the salts, solvates or hydrates thereof. Compounds of the invention are potent MMP inhibitors which advantageously do not cause tendonitis in a relevant animal model. Compounds of the invention may be expected to be of use in medicine, especially where the avoidance of side effects, such as joint pain, is desired.

Hydroxamic acid derivatives

Pharmacologically active compounds are provided as well as pharmaceutical compositions and methods for treating cancer; inflammation; an autoimmune, infectious or ocular disease; or age-related macular degeneration in a mammal.

Hydroxamic and carboxylic acid derivatives

4-(4-(-Chlorophenyl)piperazin-1-yl)sulfonylmethyl)-tetrahydor yran-4-carboxylic acid and the corresponding N-hydroxy amide, and derivatives thereof, are useful as therapeutic agents.

Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity

Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity.

Compounds having therapeutic utility are of formula (I) wherein B , B , R and R are each various sub-stituents, or R and R together form a ring.

Hydroxamic acid derivatives as matrix metalloproteinase (mmp) inhibitors

Peptidyl compounds

Disclosed are hydroxamic and carboxylic acid derivatives which are useful inhibitors of matrix metalloproteinase and/or TNF.alpha.-mediated diseases, including degenerative diseases and certain cancers.

Growing community of inventors

Cambridge, United Kingdom

Robert John Watson