The University of Queensland

Arthritis Relief Plus Ltd.

Robert John Capon

Matthew Cooper

Kanu Patel

Johannes Zuegg

Frank Roger Fontaine

Angela Aguslyarti Salim

Avril Alexis Barbara Robertson

Mathias Francois

Jeroen Overman

Larry McKay

Sreeman Kumar Mamidyala

Larry (deceased) Mckay

Disclosed are compounds of a formula provided herein that show efficacy in the inhibition of SOX18 protein activity, and in particular with respect to the ability of SOX18 to bind DNA and/or particular protein partners. Further, methods of treating angiogenesis- and/or lymphangiogenesis-related diseases, disorders or conditions, such as cancer metastasis and vascular cancers, are provided herein.

Compounds and use thereof in methods of treatment

The present invention provides a topical formulation including (i) comfrey or a comfrey-derived compound, or an analogue or derivative thereof and (ii) a penetration enhancer, and optionally including tannic acid, or an analogue or derivative thereof. The present invention also provides a topical formulation including (i) comfrey or a comfrey-derived compound, or an analogue or derivative thereof, and (ii) tannic acid, or an analogue or derivative thereof, optionally including a penetration enhancer. Also provided are kits and methods of prophylactic or therapeutic treatment of inflammatory and/or degenerative conditions using the combination of active ingredients as herein described.

Topical formulation and uses thereof

Inhibitors of SOX18 protein activity for treating angiogenesis-and/or lymphangiogenesis-related diseases

The present invention provides a topical formulation including (i) comfrey or a comfrey-derived compound, or an analog or derivative thereof and (ii) a penetration enhancer, and optionally including tannic acid, or an analog or derivative thereof. The present invention also provides a topical formulation including (i) comfrey or a comfrey-derived compound, or an analog or derivative thereof, and (ii) tannic acid, or an analog or derivative thereof, optionally including a penetration enhancer. Also provided are kits and methods of prophylactic or therapeutic treatment of inflammatory and/or degenerative conditions using the combination of active ingredients as herein described.

Growing community of inventors

Pullenvale, Australia

Robert John Capon