Other

Human Genome Sciences, Inc.

Beatson Institute for Cancer Research

Robert John Benjamin Nibbs

Vikram P Patel

Theodora W Salcedo

Gerard John Graham

The present invention relates to deletion and substitution mutant polypeptides of human chemokine &#x3b2;-7 (Ck&#x3b2;-7), as well as nucleic acid molecules encoding such polypeptides and processes for producing such polypeptides using recombinant techniques. In one aspect, the invention also relates to uses of the full-length and mature forms of Ck&#x3b2;-7, as well as deletion and substitution mutants, in medical treatment regimens. In particular, the Ck&#x3b2;-7 polypeptides described herein may be employed to treat a variety of conditions, including rheumatoid arthritis, inflammation, respiratory diseases, allergy, and IgE-mediated allergic reactions.

Chemokine &#x3b2;-7 variants

The present invention relates to deletion and substitution mutant polypeptides of human chemokine &bgr;-7 (Ck&bgr;-7), as well as nucleic acid molecules encoding such polypeptides and processes for producing such polypeptides using recombinant techniques. In one aspect, the invention also relates to uses of the full-length and mature forms of Ck&bgr;-7, as well as deletion and substitution mutants, in medical treatment regimens. In particular, the Ck&bgr;-7 polypeptides described herein may be employed to treat a variety of conditions, including rheumatoid arthritis, inflammation, respiratory diseases, allergy, and IgE-mediated allergic reactions.

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Glasgow, United Kingdom

Robert John Benjamin Nibbs