University of Georgia Research Foundation, Inc.

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Robert Jeff Hogan

Ralph A Tripp

Jackelyn Murray

Mathias D Viard

Robert P Blumenthal

Yossef Raviv

Stephen Mark Tompkins

Compositions and methods of treating a subject for a coronavirus infection are provided. The methods typically include administering the subject an effective amount of probenecid, a metabolite or analog thereof, or a pharmaceutically acceptable salt thereof. The methods can by therapeutic and/or prophylactic. The amount of probenecid or a pharmaceutically acceptable salt thereof can be effective to, for example, reduce viral replication, reduce one or more symptoms of disease, disorder, or illness associated with virus, or a combination thereof. In preferred embodiments, the virus is a Severe acute respiratory syndrome-related coronavirus such as SARS-CoV-2 or SARS-CoV, a Middle East respiratory syndrome-related coronavirus such as MERS-CoV, or a coronavirus that causes the common cold.

Methods of using probenecid for treatment of coronavirus infections

The invention provides compositions of inactivated influenza virus that can be used as vaccines and immunological compositions useful for inhibiting, preventing and treating influenza.

Inactivated influenza virus compositions

Growing community of inventors

Watkinsville, GA, United States of America

Robert Jeff Hogan