Second Sight Medical Products, Inc.

The Johns Hopkins University

Other

Second Sight, LLC

Cortigent, Inc.

Doheny Eye Institute

Second Sight Products, Inc.

Trufuse International Ltd.

Robert Jay Greenberg

Neil Hamilton Talbot

James Singleton Little

Kelly Hobart McClure

Jordan M Neysmith

Arup Roy

Jerry Ok

Brian V Mech

Mark Salman Humayun

Matthew J McMahon

Rongqing Dai

Dao Min Zhou

Joseph H Schulman

Avraham I Caspi

Richard Agustin Castro

Da-Yu Chang

David Daomin Zhou

Sumit Yadav

Richard P Williamson

Ione Fine

Chunhong Zhou

Jessy D Dorn

Alan Matthew Horsager

Scott M Loftin

John J Reinhold

Pishoy Maksy

Kevin Wilkin

Kea-Tiong Tang

Mark Humayan

Alfred E Mann

James David Weiland

Sanjay Gaikwad

Abraham N Seidman

Dau Min Zhou

Francesco Merlini

Rajat N Agrawal

Qingfang Yao

Honggang Jiang

Lucien D Laude

Scott Greenwald

Amy Hines

Devyani Nanduri

Lee Jay Mandell

Reza P Rassool

Boozarjomehr Faraji

Geoffrey M Boynton

Kevin Jun Ha

Amy Chu Peishuan Hines

Jack W Judy

Dustin Tobey

Gislin Dagnelie

Dilek Guven

Proyag Datta

Andy Hung

Gaillard R Nolan

Karl-Heinz Ihrig

DaoMin Zhou

Ashish Ahuja

Susan McCord

Donald Webber

Gregoire Cosendai

Neha Vyas

Brian Coley

Xiaofan Wu

Samip Shah

Fatima Anaflous

Eugene De Juan, Jr

Neha J Parikh

John Charles Gord

Satinderpall Singh Pannu

James Courtney Davidson

Gregory Jay DelMain

R Scott Rader

Alexander C Walsh

Timothy M Nugent

Phillipe John Tabada

Peter Meilstrup

Eugene deJuan, Jr

David Marsh

Andrew Sha

Thomas Lauritzen

Brianna Thielen

Jianing Wei

Deborah Sigel

Walter P Little

Hendrik Christiaan Stronks

Jordan Matthew Nevsmith

Kevin Wilkins

Mohamed Khaldi

Jose-Alain Sahel

Matthew S Johannes

Ryan J Murphy

Kevin David Wolfe

Philippe Martin Burlina

Seth D Billings

Kapil D Katyal

Mark D Welch

Derek M Rollend

E J Chichilnisky

The present invention consists of an implantable device with at least one package that houses electronics that receives input data or signals, and optionally, power, from an external system through at least one coil attached to the at least one package, processes the input data and delivers electrical pulses to neural tissue through at least one array of multiple electrodes that is/are attached to the at least one package. The invention, or components thereof, is/are intended to be installed in the head, or on or in the cranium, or on the dura, or on or in the brain.

Implantable device for the brain

The present invention is a cortical visual prosthesis. The cortical visual prosthesis includes an implanted portion and an external portion. The implanted portion includes an implanted coil, electronics package, and a plurality of electrodes adapted to stimulate neural tissue. The implanted coil transfers power and data to the electronics package and the electronics package drives the electrodes. The external portion includes a video processor and a pair of glasses adapted to be supported by a user's nose and ears. The glasses include a support adapted to hold an external coil in close proximity to the implanted coil when implanted; the external coil supplies power and data to the implanted coil.

Visual cortical prosthesis

A method for manufacturing a flexible circuit electrode array, comprising: A layer of polymer is laid down. A layer of metal is applied to the polymer and patterned to create electrodes and leads for those electrodes. A second layer of polymer is applied over the metal layer and patterned to leave openings for the electrodes, or openings are created later by means such as laser ablation. Hence the array and its supply cable are formed of a single body. Alternatively, multiple alternating layers of metal and polymer may be applied to obtain more metal traces within a given width. The method provides an excellent adhesion between the polymer base layer and the polymer top layer and insulation of the trace metals and electrodes.

Flexible circuit electrode array and method of manufacturing the same

A peripheral nerve stimulator configured as a flexible circuit to stimulate or block the operation of a nerve or nerve bundle, including electrode array, cable and bond pad portions connected to an electronics package. The electrode array is configured for peripheral nerve modulation and may be curved cylindrically to encompass a nerve. A cylindrical curve can be imparted through thermoforming or by applying a stretchable polymer. The stretchable polymer places the electrode array portion into a cylinder when the electrode array portion is in a relaxed position. The electronics package includes low profile, stacked thin chip electronic components that are tunable in-situ, requiring less vertical and lateral space than stacked passives. The thin chip components may be high density trench capacitors, metal-on-semiconductor capacitors positioned on an integrated circuit chip. The thin chip components may include metal-insulator-metal capacitors having a tunable capacitance value and/or may be a binary capacitor array.

Flexible circuit peripheral nerve stimulator with low profile hybrid assembly

The present invention is a system for detecting, tracking and recognizing human faces in a visual prosthesis. In a visual prosthesis, the input camera is always higher resolution than the electrode array providing percepts to the subject. It is advantageous to detect, track and recognize human faces. This information can be provided to the subject by highlighting the face in the visual scene, providing auditor or vibratory notice that a human face is in the visual scene, looking up the face in a database to identify and annunciate the name of the person in the visual scene, or otherwise communicate the identity of the person, like providing a custom vibratory pattern corresponding to known individuals (like custom ring tones associated with caller ID) or automatically zooming in on a face to aid the subject in identifying the face.

Face detection tracking and recognition for a visual prosthesis

The present invention is a method of processing a video image in an electronic video processor, including the steps of receiving an input image having an input field of view, generating a processed image from the input image, and having an output field of view smaller than the input field of view, searching for a predetermined pattern within the input image, providing an indication when the predetermined pattern is found in the input image, zooming the processed image to the input field of view and highlighting the predetermined pattern in the processed image in response to the indication.

Pattern detection and location in a processed image

In electrically stimulating neural tissue it is important to prevent over stimulation and unbalanced stimulation, which would cause damage to the neural tissue, the electrode, or both. It is critical that neural tissue is not subjected to any direct current or alternating current above a safe threshold. Further, it is important to identify defective electrodes, as continued use may result in neural damage and further electrode damage. The present invention presents system and stimulator control mechanisms to prevent damage to neural tissue.

Method and apparatus to provide safety checks for neural stimulation

Electrode arrays for biological implants are disclosed. The present disclosure provides array designs for improving apposition (reducing the space between the array and neural tissue). The present disclosure also provides electrode array designs that can be made approximately spherical to increase the field of view of a visual prosthesis while still maintaining good apposition to neural tissue.

Electrode array

The invention is a method of automatically adjusting a visual prosthesis electrode array to the neural characteristics of an individual patient. By recording electrically evoked responses to a predetermined input stimulus, one can alter that input stimulus to the needs of an individual patient. A minimum input stimulus is applied to a patient, followed by recording an electrically evoked response to the input stimulus. By gradually increasing stimulus levels, one can determine the minimum input that creates a neural response, thereby identifying the threshold stimulation level. One can further determine a maximum level by increasing stimulus until a predetermined maximum neural response is obtained.

Method and apparatus for fitting a visual prosthesis using electrically evoked responses

The present invention is an improved system for use of eye tracking including spatial mapping percepts in a visual prosthesis by presenting an electrically induced precept through a visual prosthesis, requesting a subject look to the direction of the percept and tracking their eye movement. Eye movement is both faster and more accurate than asking a visual prosthesis user to point to the location of a percept. This method can be beneficial in a retinal prosthesis, but is particularly useful in a cortical visual prosthesis where visual cortex does not match the retinotopic map. Methods are presented for calibrating an eye tracker. Eye tracking hardware may also be used for blanking video information base on the subject's natural blink reflex.

Uses for eye tracking in a visual prosthesis

The present invention is an improved visual prosthesis including a video processing unit with user controls optimized for use by blind individuals. The controls include easily identifiable shapes. The controls are programmable to provide improved usability with a simple tactile interface.

Visual prosthesis including an improved video processing unit

The present invention is a fitting system with a graphical interface with specific interface screens for specific functions. Methods and devices for fitting a visual prosthesis are described. In one of the methods, threshold levels and maximum levels for the electrodes of the prosthesis are determined and a map of brightness to electrode stimulation levels is later formed. A fitting system for a visual prosthesis is also discussed, together with a computer-operated system having a graphical user interface showing visual prosthesis diagnostic screens and visual prosthesis configuration screens.

Visual prosthesis fitting

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Los Angeles, CA, United States of America

Robert Jay Greenberg