Syntex (u.s.a.) Inc.

Roche Palo Alto LLC

Other

F. Hoffmann-la Roche Ag

Robert James Weikert

David Garrett Loughhead

Ann Marie Madera

Ryan Craig Schoenfeld

David John Morgans, Jr

David Bernard Smith

Eric Brian Sjogren

Ronald Charles Hawley

Peter H Nelson

Jean-Marc Plancher

John W Patterson

Todd Richard Elworthy

Alicia Cervantes

Dean R Artis

Teresa Lara

Fidencio Franco

Ann M Waltos

Alejandra Trejo

Matthew C Lucas

Pravin Iyer

Mario Fernandez

Francisco X Talamas

Lee Allen Flippin

Russell Stephen Stabler

Stephen Matthew Lynch

Robert J Greenhouse

John C Rohloff

Saul Jaime-Figueroa

Francisco Xavier Talamas

Elbert Chin

David Scott Carter

Karin Ann Stein

Sharada Shenvi Labadie

Jacob Berger

Qingjie Ding

Eric Mertz

Clara Jeou Jen Lin

Christine E Brotherton-Pleiss

Nan Jiang

Stephen Deems Gabriel

Zhi Chen

Francisco X Talam As

Lubica Raptova

Kerem Erol Ozboya

Eun Kyung Lee

Joseph Anthony Bilotta

Mario Fern Andez

Marzia Villa

Xiao-Fa Lin

Deborah Carol Reuter

Fancisco X Talamas

Han Ma

John Cureton Hunter

Shawn David Erickson

Stephen M Lynch

Clara Jeou Lin

Klaus Klumpp

Robert Greenhouse

Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives and uses thereof

This application discloses compounds of generic Formula I: or pharmaceutically acceptable salts thereof, wherein A, R, R, R, R, Q, X, Y, m, p, and q are defined as described herein, useful for treatment of diseases associated with monoamine reuptake inhibitors. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.

Substituted indolyl and indazolyl derivatives and uses thereof

This application discloses aminopiperidinyl compounds of generic Formulae I-II: or pharmaceutically acceptable salts thereof, wherein m, r, Q, Q, Q, R, R, R, R, R, and Rare defined as described herein, useful for treatment of diseases associated with monoamine reuptake inhibitors. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.

Aminopiperidinyl derivatives and uses thereof

Compounds of the formula: or pharmaceutically acceptable salts thereof,wherein m, n, Ar, R, R, Rand Rare defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.

Pyrrolidinyl and piperidinyl ketone derivatives and uses thereof

Compounds having the formula I wherein R, R, R, R, Rand X are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication. 

Heterocyclic antiviral compounds

Compounds of formula I: or pharmaceutically acceptable salts thereof, wherein Ar is indolyl, indazolyl or dihydroindolyl, and R, R, Rand Rare as defined herein. Also provided are pharmaceutical compositions, methods of using the compounds in the treatment of depressive, anxiolytic and other disorders associated with inhibition of the reuptake of norepinephrine, serotonin, and dopamine, and methods of preparing the compounds.

Arylpiperazine derivatives and uses thereof

Compounds of formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof,

3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors

The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof,wherein p, Ar, R, R, R, R, R, R, Rand Rare defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.

3-amino-1-arylpropyl indoles and AZA-substituted indoles and uses thereof

Compounds of the formula: or pharmaceutically acceptable salts thereof,wherein m, n, X, Y, Z, Ar, R, R, R, R, R, Rand Rare defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.

The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R, R, R, R, R, R, Rand Rare defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.

3-Amino-1-arylpropyl azaindoles and uses thereof

Compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof,wherein Ar, Rand Rare defined herein. Also provided are pharmaceutical compositions, methods of preparing the compounds, and method of using the compounds for treatment of monoamine reuptake inhibitor-mediated diseases.

Benzazepine derivatives and uses thereof

3-amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof

The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R, R, R, R, p and n are those defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I.

2,4-substituted indoles and methods of use

The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R, R, R, R, and n are those defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I.

2,7-substituted indoles

This invention relates to the (R)-isomers of compounds which are generally muscarinic receptor antagonists and which are represented by Formula I:wherein p, R, R, Rand A are as defined in the specification, or individual isomers, racemic or non-racemic mixtures of isomers, or acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use and preparation as therapeutic drugs.

4-piperidinyl alkyl amine derivatives as muscarinic receptor antagonists

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Boulder Creek, CA, United States of America

Robert James Weikert