Ge Healthcare Limited

Ge Healthcare As

Robert James Nairne

Bengt Langstrom

Anthony Eamon Storey

Farhad Karimi

Alexander Mark Gibson

Steven Michael Fairway

Lorenzo Williams

Clare Louise Jones

Denis Raymond Christophe Bouvet

Torgrim Engell

Andreas Richard Meijer

Imtiaz Ahmed Khan

Graeme McRobbie

Nicolas Lasbistes

Gareth Simon Getvoldsen

Alan Cuthbertson

Matthias Eberhard Glaser

Sajinder Kaur Luthra

Jane Brown

Nicholas Lasbistes

Imitiaz Ahmed Khan

The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to radiotracer compositions which comprisesF-labelled c-Met binding peptides. The invention provides said compositions, as well as associated automated methods of preparation and cassettes.

Radiotracer compositions and methods

[F]-fluoralkyl tosylates are useful building block for the radiosynthesis of a number of small molecules. A method of purifying [F]-fluoroalkyl tosylates using an automated radiosynthesis apparatus (e.g. FASTlab module) is described. A method of purifying [F]-fluoroalky tosylates using a FASTlab module that includes a solid phase extraction (SPE) purification system is described.

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The invention relates to a process for preparation of a compound of formula (I): Ris selected from Calkyl, Calkenyl, and Calkynyl;which comprises:(i) reaction with fluoride, suitably [F]fluoride, of a corresponding compound of formula (II): wherein Ris selected from hydrogen, Calkyl, Chaloalkyl, Caryl, Carylalkyl, &#x2014;(CHCHO)&#x2014;CHwherein q is an integer of from 1 to 10;Ris as defined for the compound of formula (I); andRis a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.

Fluorination process

The invention relates to a process for preparation of a compound of formula (I): Ris selected from Calkyl, Calkenyl, and Calkynyl; which comprises: (i) reaction with fluoride, suitably [F]fluoride, of a corresponding compound of formula (II): wherein Ris selected from hydrogen, Calkyl, Chaloalkyl, Caryl, Carylalkyl, &#x2014;(CHCHO)&#x2014;CHwherein q is an integer of from 1 to 10; Ris as defined for the compound of formula (I); and Ris a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed. 

Fluorination process of anilide derivatives and benzothiazole fluorinate derivatives as in vivo imaging agents

The invention relates to new peptide-based compounds and their use in diagnostic optical imaging techniques. More specifically the invention relates to the use of such peptide-based compounds as targeting vectors that bind to receptors associated with angiogenesis. The compounds are labelled with at least one cyanine dye reporter and may be used as contrast agents in optical imaging in diagnosis of angiogenesis-related diseases.

Peptide based-compounds

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Amersham, United Kingdom

Robert James Nairne