Ge Healthcare Limited

Hammersmith Imanet Limited

Robert James Domett Nairne

Harry John Wadsworth

Michelle E Avory

Erik Arstad

Matthias Eberhard Glaser

Rajiv Bhalla

Imtiaz Ahmed Khan

Edvin Wilhelm Johannesen

Anthony Wilson

Jane Brown

Andrew John Healey

Andres Black

Andrew Black

The present invention provides novel radioiodinated fatty acids. Also provided are methods of preparation of said radioiodinated fatty acids from non-radioactive precursors, as well as radiopharmaceutical compositions comprising such radioiodinated fatty acids. The invention also provides in vivo imaging methods using the radioiodinated fatty acids.

Radioiodinated fatty acids

The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, in a preferred embodiment, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimized.

Method for the synthesis of 18F-labelled molecules

The present invention provides a novel method of labelling biological targeting molecules (BTMs) of interest with radioiodine. Also provided are functionalised BTMs useful in the method, as well as methods of preparing such functionalised BTMs under mild conditions.

Radioiodination method

The present invention relates toF radio-chemistry and in particular to a method for synthesising radiofluorinated amides and amines. The method of the invention has particular application in the radiosynthesis of a variety ofF-labelled positron emission tomography (PET) tracers.

Radiofluorination

The present invention relates to labelled cMet binding peptides suitable for optical imaging in vivo. The peptides are labelled with a benzopyrylium dye suitable for imaging in the red to near-infrared region. Also disclosed are pharmaceutical compositions and kits, as well as in vivo imaging methods, especially of use in the detection, staging, diagnosis, monitoring of disease progression or monitoring of treatment of colorectal cancer (CRC).

Peptide imaging agents

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Amersham, United Kingdom

Robert James Domett Nairne