The Upjohn Co.

Robert James Collins

James H Ludens

Lester J Kaplan

Charles E Coverdale

Philip F Von Voigtlander

Conditions of inappropriate hyperhydration in warm blooded animals can be treated with an essentially water only diuretic drug compound selected from the group ##STR1## wherein m, n, p, A, E, R, R.sub.1, R.sub.2, X, Y and Z are as defined in the specification, e.g., trans-3,4-dichloro-N-methyl-N-[7-(1-pyrrolidinyl)-1,4-dioxaspiro[4.5]dec-8 -yl]benzeneacetamide, or a pharmaceutically acceptable salt thereof, ##STR2## wherein R, R.sub.1, R.sub.2, R.sub.3, P, Q, X and Y are as defined in the specification, e.g., 3,4-dichloro-N-[[8-(1-pyrrolidinyl)-1,4-dioxaspiro[4.5]-dec-8-yl]methyl]be nzeneacetamide, or a pharmaceutically acceptable salt thereof, or ##STR3## where R, R.sup.1, R.sup.2, X and Y are as defined in the specification, e.g., trans-(1)-2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] acetamide,

Oxygen substituted amino-cyclohexyl-benzeneacetamides and -benzamides as

Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen or lower alkyl, R.sub.3 represents lower alkyl and A is a monovalent group of formula: ##STR2## wherein Y is hydrogen or the acyl radical of a hydrocarbon carboxylic acid having from 2 to 18 carbon atoms, inclusive, are employed as anticonvulsants in treating mammals, including humans. Novel compounds within the scope of the above formula are also disclosed, wherein R.sub.1 is specifically lower alkyl and provided that R.sub.1 is located in a position ortho or meta to the substituent group A when R.sub.2 is hydrogen. Disclosed also are novel intermediate compounds for preparing the above-described novel compounds of the invention, which correspond thereto but wherein the group A is replaced by a nitro-group.

Compositions and method for treating epilepsy and convulsions

An animal feed comprising a compound of the group consisting of 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines of the formula: ##STR1## WHEREIN R is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms, inclusive, phenyl, benzyl and -COOR' in which R' is alkyl of 1 to 4 carbon atoms, inclusive; wherein R.sub.1 is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms, inclusive; and wherein R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms, inclusive, halogen, nitro, cyano, trifluoromethyl, and alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoylamino and dialkylamino in which the carbon chain moieties are of 1 to 3 carbon atom, inclusive and their pharmacologically acceptable acid addition salts in combination with a nutrient feed. A process for obtaining increased productivity in meat producing, milk producing, and egg laying animals by feeding the aforementioned compounds in combination with nutrient feeds.

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Portage, MI, United States of America

Robert James Collins