Rhone-poulenc Chimie

Societe D'expansion Scientifique Expansia

Robert Jacquier

Jacques Daunis

Christian Aspisi

Bernard Calas

Michel Follet

Jean Verducci

Joseph Parello

Monique Calmes

Virginie Pevere

Marc Bonato

Michel Ibea

The present invention relates to chiral supports and to their use in the asymmetric synthesis, deracemization and optical inversion of organic chiral compounds. In particular, the supports are used in combination with thermal equilibration of a species having a reactive achiral portion. Preferably, these supports are obtained by the copolymerization of at least one chiral unit and at least one functionalizing unit or by the polymerization of at least one chiral unit which is a source of said functionalizing unit. Optionally, a crosslinking agent is utilized. By utilizing these supports and thermal equilibration, excess enantiomers can be produced.

Chiral polymers for the production of excess enantiomers

The present invention relates to chiral polymers and to their uses for operations of asymmetric synthesis, deracemization and optical inversion. These polymers are characterized in that they comprise:

Chiral polymers for the synthesis of pure enantiomers of amino acids

The present invention relates to a process for preparing optically active synthons, in which an oxygen-silylated amino acid or peptide having a protected nitrogenous group, is activated by a non-coordinated halogenated phosphorus derivative and is condensed with an N-silyl amino acid or peptide in which the acid group is protected.

Process for preparing peptide synthons

The present invention relates to a process for preparing peptide synthons in which the optical purity of each of the peptides to be condensed is retained. According to this process, a silyl derivative of an amino acid or peptide, which is activated by a complex chloroimmonium salt, a complex coordinated phosphorus halide, oxyhalide salt or a complex oxalyl halide salt, is prepared. The activated peptide is then condensed with an N-silyl amino acid or peptide in which the acid group is protected.

The invention relates to new reticulated statistic acrylic copolymers that may be used in a very wide range of solvents (water, methylene chloride, chloroform, methanol, ethanol, dimethylformamide, pyridine,) stable between pH 1 and pH 14, to preparation process thereof and to their use in ion exchange chromatography.

Acrylic copolymers of N-acryloylpolymethyleneimines or

The present invention relates to new amino-functionalized acrylic copolymers, their preparation and their use in peptide synthesis.

Acrylic copolymers and their use in solid phase peptide synthesis

This invention relates to new chiral organoboranes of the general formula ##STR1## in which X represents a methylene group or a sulphur atom, n and p are 0 or 1, and to a preparation process of these compounds, consisting in reacting a bicyclic substituted di- or tri-thiane with a borane such as B.sub.2 H.sub.6 or BH.sub.3 : Lewis base.

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Montpellier, France

Robert Jacquier