Monsanto Company

Robert J Slocombe

Joseph E Fields

The invention concerns compositions for producing adherent polymeric coatings on a variety of substrates. The coating compositions comprise polymeric latices of colloidal polymer particles of at least one polymer capable of being deposited in the form of a film. In addition to the film-forming polymer, the coating composition comprises a discrete latex component which is a precursor of a material aiding rapid film formation through inter-reaction with the polymer particles, and may also have an affinity toward the substrate so as to function as a linking agent. This material can cause film formation by disrupting the colloidal stability of the polymer particles. It is possible to select as the discrete latex component a precursor of a material which has the dual function of increasing speed of film formation while fostering the adherence and bonding of the film to the substrate because of the material's relative affinities for the polymer and for the substrate.

Aqueous polymeric latex coating compositions, products produced thereby,

Blood coagulation factors such as Factor VIII are separated from admixture with other blood proteins without producing activation of said coagulation factors by contacting with a water-insoluble, cross-linked polyelectrolyte copolymer of (a) C.sub.2-18 unsaturated monomer and (b) C.sub.4-12 unsaturated polycarboxylic acid or anhydride which is partially substituted at its free carboxyl or anhydride sites with amine-imides and in which substantially all the remaining free carboxyl or anhydride sites are blocked with alkoxyalkylamine to form alkoxyalkylimide units.

Separation of blood coagulation factors with non-activating

The filterability, drying characteristics and physical form of water-insoluble, cross-linked polyelectrolytes containing amine-imide functional groups is improved without substantially diminishing the protein adsorption capacity of said polyelectrolytes by heating the polymeric starting material in inert organic solvent at a temperature ranging from about 115.degree. C to about 160.degree. C but lower than the softening point of said polymer for at least about 15 minutes and until said polymer is substantially aggregated prior to crosslinking.

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St. Louis, MO, United States of America

Robert J Slocombe