Takeda San Diego, Inc.

Takeda California, Inc.

Robert J Skene

David J Hosfield

Leslie William Tari

Jeffrey Alan Stafford

Mark Knuth

Bi Ching Sang

Sheng Ye

Jun Feng

Stephen L Gwaltney

Sheldon Cao

Mingnam Tang

Mark Hilgers

Alexei Brooun

Ciaran N Cronin

Duncan E McRee

Robert A Wijnands

Kathleen Aertgeerts

Stephen W Kaldor

Ellen Chi

Jason W Brown

Keith P Wilson

Ronald V Swanson

Anthony R Gangloff

Phong H Vu

Andrew John Jennings

Jerome C Bressi

Sridhar Govinda Prasad

Douglas R Dougan

Ellen Chien

Hua Zou

Oleg Brodsky

Marc E Navre

Darbi Witmer

David J Hossfield

Sheldon X Cao

Compounds are provided which have the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture which contain such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to activate glucokinase.

Substituted isoindoles as glucokinase activators

Compounds are provided for use with hexokinases that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Substituted indazoles as glucokinase activators

Compounds, pharmaceutical compositions, kits and methods are provided for use with histone deacetylases (HDACs) that comprise a compound of the formulae: wherein the variables are as defined herein.

Histone deacetylase inhibitors

Provided are crystals relating to histone deacetylase 2 (HDAC-2) and its various uses.

Crystallization of histone deacetylase 2

Provided are crystals relating to DPPIV and its various uses.

Crystallization of dipeptidyl peptidase IV (DPPIV)

Provided are crystals relating to Cathepsin S and its various uses.

Crystallization of cathepsin S

Provided are crystals relating to MvaS (HMG-CoA Synthase) and its various uses.

Crystallization of MvaS (HMG-CoA Synthase)

Provided are crystals relating to 11-Beta-Hydroxysteroid Dehydrogenase type 1 and its various uses.

Crystallization of 11-Beta-Hydroxysteroid Dehydrogenase type 1

Provided are structure coordinates relating to MvaS and its various uses.

Crystal structure of MvaS

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San Diego, CA, United States of America

Robert J Skene