Becton Dickinson and Company Limited

Robert J Losada

Fu-Chung Lin

Gregory L Lusardi

Hugh T Conway

Jeffrey P Radziunas

Dimitrios Manoussakis

Paul C DiCesare

C Mark Newby

Klaus W Berndt

Christopher Austin Battles

Joel L Williams

Timothy A Stevens

Jeffrey A Karg

Benjamin R Bartfeld

Jamieson W Crawford

Song Shi

Edward L Nugent

Ravi Attri

David B Montgomery

Gregory R Hires

Gary D Fletcher

Ajit N Dastane

Henry F Miller

Girish Parmar

Paul R Soskey

Tatsuhiko Ikeda

Sol F Green

Arun U Nair

Yuguang Wu

Myriam Lopez

Mei Yang

A method for detecting the presence of a microorganism in a fluid sample is disclosed. The method includes providing a fluid specimen within a specimen collection container having a sidewall defining an interior therein. The interior includes a mechanical separator adapted for separating the fluid sample into first and second phases within the specimen collection container and a sensing element capable of detecting the presence of a microorganism disposed therein. The method includes subjecting the specimen collection container to applied rotational force to isolate a concentrated microorganism region. The method also includes detecting by a sensing element the presence or absence of a microorganism within the concentrated microorganism region.

Method and apparatus for microorganism detection

Disclosed is a fluid collection device wherein multiple, individual samples of fluid can be collected simultaneously. The device includes a chamber and an adapter which substantially and simultaneously distributes the blood to individual chambers with chamber specific additives. Also included is a system for using the blood collection device, preferably within a diagnostic testing laboratory.

Blood collection device, method, and system for using the same

A separation assembly for separation of a fluid into first and second parts is disclosed. A container has a first end, a second end, and a sidewall extending therebetween defining an interior, the container defining a longitudinal axis between the first end and the second end. A separator body is disposed within the interior having a through-hole defined therethrough. The separator body includes a first part, and a second part interfaced with the first part, wherein the separator body is transitionable from a first position wherein the through-hole is provided in fluid-receiving alignment with the first end of the container, to a second position wherein the through-hole is provided substantially perpendicular to the longitudinal axis of the container. In the first position, a through-axis of the through-hole of the separator body is in a plane that is not parallel with a plane containing the longitudinal axis of the container.

Mechanical separator for a biological fluid

A separator for use in a container for a biological fluid is disclosed. The separator includes a separator body having a first region at least partially made of a first material having a first density, and a second region at least partially made of a second material having a second density different from the first density. The separator has an overall density intermediate the densities of a first phase and a second phase of the biological fluid. At least a portion of the separator is deformable between a first condition in which the biological fluid can pass between an inner surface of the container and the separator, and a second condition in which at least a portion of the separator prevents the biological fluid from passing between the inner surface of the container and the separator.

Device for separating components of a fluid sample

A device for separating heavier and lighter fractions of a fluid sample is provided, the device including a container and a unitary separator located therein, the separator having an overall density between the heavier and light fractions. The separator is capable of moving between the fractions upon centrifugation, and sealing the fractions from one another when centrifugation ends.

A device for separating plasma from whole blood is provided having an evacuated primary collection chamber capable of fluid communication through a porous filter to an evacuated secondary collection chamber. An agglutinating agent is provided within the primary collection chamber so as to aggregate blood cells within a whole blood sample. The porous filter has a pore size which is small enough to capture the aggregated blood cells therein, yet large enough to permit plasma to transfer therethrough under pressures associated with conventional evacuated blood collection tubes. The primary and secondary collection chambers may be provided in separate containers or tubes, with transfer occurring therebetween through a transfer device including the porous filter therein.

Plasma on demand tube

A device and method for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents comprising a container and a composite element in the container. The composite element is a separator comprising a deformable bellows, a ballast mounted to the lower end of the bellows, and a float is engageable with an upper end of the bellows. A fluid sample is delivered to the container and the device is subjected to centrifugation whereby the centrifugal load causes the ballast to move toward the bottom of the tube and causes an elongation and narrowing of the bellows. The separator then moves down the tube and stabilizes in a position between the separated phases of the fluid sample. Termination of the centrifugal load enables the bellows to return to its original condition in sealing engagement with the walls of the tube. The dense formed phase of the fluid sample will lie between the separator and the bottom of the tube, while less dense liquid phase of the fluid sample will be the separator.

Device and method for separating components of a fluid sample

A device and method for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents comprising a container and a composite element in the container. The composite element is a separator comprising at least two components and more particularly, a bellows with a seal body, a low-density float and a high-density ballast. A fluid sample is delivered to the container and the device is subjected to centrifugation whereby the centrifugal load causes the seal body of the separator to deform so that the separator migrates through the fluid sample and then stabilizes between the heavier and lighter fractions of the fluid sample. The seal body of the separator will resiliently return to its initial configuration upon termination of the centrifugal load such that the seal body sealingly engages the container and the composite element separates the heavier and lighter fractions of the fluid sample.

A blood collection device comprising formed additive particles. The additive particles are an improvement over available additive formulations that are powder blended in that the components of the additive particles of the present invention are in each formed particle. The formed additive particles comprise a fluoride salt and an ethylenediaminetetraacetate salt or a heparin salt to consistently minimize glycolysis and coagulation of a blood specimen with low hemolysis.

Apparatus for inhibiting glycolysis in blood samples

A blood collection assembly includes a plasma-treated blood collection container and a blood collector which optionally may also be plasma-treated. The collector has a body portion providing a blood passageway between the container and a scoop shaped portion which contacts a puncture wound. A vent in the collector allows air displacement from the container when blood enters. The inside wall of the container has longitudinal ribs molded thereon and an altered surface chemistry characterized by an enhanced oxygen content. The invention includes a method to increase blood flow across the interior surface of a plastic blood collection container comprising plasma treatment of the surface.

Platelet stable blood collection assembly

An arrangement is provided for inducing rapid flow of a blood sample into a collection assembly for the sample, with the arrangement including an elongated member of narrow width positioned in the flow path of the blood from the source therefore to the collection area therefore. The member of the invention may be, for example, an elongated flat strip, flexible or rigid, a solid rod, a solid strip square in cross section, or a tubular rod. The elongated device may be separate and positioned or adhered to a surface forming the blood flow path or it may be molded simultaneously with a collection assembly. The device may serve to provide a bridging transition from the surface of one part of an assembly to another. Finally, the device may be used to induce sample flow back and forth in a collection tube during mixing.

Flow inducing means for small volume containers

A cap is provided for a blood microcollection container which cap incorporates a partially open tubular and tapered scoop arrangement for engaging a puncture wound, and rapidly receiving blood from the wound. Longitudinally extending ribs serve to define and maintain a blood flow and an air venting passage in the collector, while preventing blood 'hang-up' caused by capillary action in the blood flow passage of the collector. With this invention, the time of transfer is reduced substantially because less precise positioning is required of the scoop, and blood 'hang-up' in the transfer passage is avoided.

Growing community of inventors

Astoria, NY, United States of America

Robert J Losada