Purdue Pharma L.p.

Rhodes Technologies

Purdue Pharmaceuticals L.p.

The P.f. Laboratories, Inc.

Euro-celtique S.a.

Rhodes Pharmaceuticals L.p.

Other

Rhodes Pharmaeuticals, L.p.

Robert J Kupper

Donald Kyle

Qi Hong

Lonn S Rider

Robert Chapman

Raymond C Glowaky

Andreas Stumpf

Sibao Chen

Akwete L Adjei

Vincent Mancinelli

Gennady Nisnevich

Arie L Gutman

Igor Rukhman

Lev Yudovich

Kenneth I Sawyer

F Peter Boer

Disclosed in certain embodiments is an immediate release solid oral dosage form comprising a plurality of particles, each particle comprising: (i) a core comprising a first active agent; (ii) a coating comprising a second active agent layered over the core; and (iii) a material that is sensitive to acidic pH layered over the coated core; wherein the dosage form releases at least about 70% of the second active agent within 45 minutes as measured by in-vitro dissolution in a USP Apparatus 2 (paddle) at 50 rpm in 500 ml 0.1 N HCl at 37° C.

Tamper resistant immediate release formulations

In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.

Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone

This invention relates to opioid ketal compounds of Formula (I), Formula (II), or Formula (III): or a pharmaceutically acceptable salts thereof, wherein Ris H or CH, Ris H or OH, n is 0, 1, 2 or 3, Rand Rare independently H or optionally substituted C-Calkyl, or when n is 0, then Rand Rand the carbon atoms to which they are attached together form six, or seven membered ring, which is optionally mono or disubstituted by C-Calkyl. The invention also relates to oxycodone ketal compounds of Formula (IV) or (V): or a pharmaceutically acceptable salts thereof. The invention also relates to the use of such compounds for the treatment, prevention, or amelioration of pain.

Opioid ketal compounds and uses thereof

Disclosed in certain embodiments is a system and method of providing a dronabinol oral solid dosage form with increased stability.

Systems and methods for increasing stability of dronabinol compositions

Disclosed in certain embodiments is an immediate release solid oral dosage form comprising a plurality of particles, each particle comprising: (i) a core comprising a first active agent; (ii) a coating comprising a second active agent layered over the core; and (iii) a material that is sensitive to acidic pH layered over the coated core; wherein the dosage form releases at least about 70% of the second active agent within 45 minutes as measured by in-vitro dissolution in a USP Apparatus 2 (paddle) at 50 rpm in 500 ml 0.1 N HCl at 37&#xb0; C.

This invention relates to opioid ketal compounds of Formula (I), Formula (II), or Formula (III): or a pharmaceutically acceptable salts thereof, wherein Ris H or CH, Ris H or OH, n is 0, 1, 2 or 3, Rand Rare independently H or optionally substituted C-Calkyl, or when n is 0, then Rand Rand the carbon atoms to which they are attached together form six, or seven membered ring, which is optionally mono or disubstituted by C-Calkyl. The invention also relates to oxycodone ketal compounds of Formula (IV) or (V): or a pharmaceutically acceptable salts thereof. The invention also relates to the use of such compounds for the treatment, prevention, or amelioration of pain. 

This invention relates to opioid ketal compounds of Formula (I), Formula (II), or Formula (III): or a pharmaceutically acceptable salts thereof, wherein Ris H or CH, Ris H or OH, n is 0, 1, 2 or 3, Rand Rare independently or optionally substituted C-Calkyl, or when n is 0, then Rand Rand the carbon atoms to which they are attached together form six, or seven membered ring, which is optionally mono or disubstituted by C-Calkyl. The invention also relates to oxycodone ketal compounds of Formula (IV) or (V): or a pharmaceutically acceptable salts thereof. The invention also relates to the use of such compounds for the treatment, prevention, or amelioration of pain. 

Process for preparing oxycodone hydrochloride having less than 25 PPM 14-hydroxycodeinone

Process for preparing oxycodone compositions

Growing community of inventors

Warwick, RI, United States of America

Robert J Kupper