Array Biopharma Inc.

Intermune, Inc.

Genentech, Inc.

Robert J Kaus

Steven Wade Andrews

Yutong Jiang

Timothy S Kercher

Bin Wang

Scott D Seiwert

Lawrence M Blatt

Michael Lyon

April L Kennedy

James F Blake

Eli M Wallace

Huifen Chen

Pierre Martin

Mark Joseph Chicarelli

John Joseph Gaudino

Jacob Bradley Schwarz

Peter J Mohr

Paul Nichols

Weidong Liu

Rustam Ferdinand Garrey

Andreas Schumacher

C Todd Eary

Tarek Sammakia

Christopher Stephen Siedem

Jason Demeese

Bradley Barnett

Leonid Beigelman

Gabrielle R Kolakowski

Steven Armen Boyd

Brad Owen Buckman

Kevin Ronald Condroski

Li Ren

David A Moreno

Lewis J Gazzard

Allison L Marlow

Allen A Thomas

Samuel S Kintz

Steven Mark Wenglowsky

Christopher S Siedem

Bradley R Barnett

Compounds having the formula (I) wherein R, R, Rand Ar as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders. 

Substituted quinazolines as serine/threonine kinase inhibitors

Compounds having the formula I wherein Z, ZZZ, R, Rand Rand as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders. 

Serine/threonine kinase inhibitors

The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Macrocyclic inhibitors of hepatitis C virus replication

The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments provide compounds of the general Formula II, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Peptide inhibitors of hepatitis C virus replication

Growing community of inventors

Boulder, CO, United States of America

Robert J Kaus