Bristol-Myers Squibb Compnay

Five Prime Therapeutics, Inc.

Other

Robert J Johnston

Paul O Sheppard

Arvind Rajpal

Andrew Rankin

Alan J Korman

Ginger Chao Rakestraw

Keith Sadoon Bahjat

Luis Borges

Lin Hui Su

Guodong Chen

Richard Y Huang

Ekaterina G Deyanova

Andy X Deng

Xiaodi Deng

Jason Robert Pinckney

David A Critton

Wei-Ching Liang

Akbar Nayeem

Dhaya Seshasayee

Michael Quigley

Hadia Lemar

Mahesh Yadav

Arathi Krishnakumar

Jane L Grogan

Yan Wu

Meredith Hazen

The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.

Antibodies binding to VISTA at acidic pH

Antibodies binding to vista at acidic pH

Methods of identifying and using PSGL-1 antagonists are provided. Such methods include, but are not limited to, methods of treating cancer. PSGL-1 antagonists include, but are not limited to, antibodies that bind PSGL-1 and antibodies that bind VISTA, wherein the antibodies inhibit PSGL-1 binding to VISTA, e.g., at acidic pH (e.g., pH 6.0), as well as PSGL-1 and VISTA extracellular domain polypeptides.

Method of identifying a P-selectin glycoprotein ligand-1 (PSGL-1) antagonist

Buoyant assistive device

A game apparatus including a stand having a generally horizontal platform connected to a generally upright column. The platform has a plurality of distinct sides with point value indicia associated with each of these sides. A target object is placeable on the platform and is connected to the platform by tether means. A projectile is thrown at the target object from a remote distance with the object of knocking the target object from the platform over one of said sides. The points awarded the player participant throwing the projectile depends on which of the sides of the target is knocked over.

Projectile and tethered target game apparatus

Growing community of inventors

San Mateo, CA, United States of America

Robert J Johnston