Michigan State University

Robert J Isfort

Paul M Coussens

Leland F Velicer

Hsing-Jien Kung

A gene encoding for A antigen precursor, derived from a Avian herpesvirus, is described. The gene is preferably isolated from a Marek's disease herpesvirus virus (MDHV) and is approximately 1.8-1.9 kbp, found on a DNA fragment of about 2.35 kbp in size. The gene can be used as a building block for vaccines, directly as a diagnostic hybridization probe, to facilitate preparation of diagnostic test kits for MDHV by antigen production and subsequent antibody production, and as a potential source of regulatory elements such as signal peptides or promoters for use with other proteins.

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Frederick, MD, United States of America

Robert J Isfort