Other

Myrexis, Inc.

Epicept Corporation

Myriad Pharmaceuticals, Inc.

Manfredi, John

Robert J Halter

Mark B Anderson

Yevgeniya Klimova

Warren S Weiner

Rachel M Slade

Ashantai J Yungai

Kenton Zavitz

Ruth J Walton

Jon Adam Willardsen

Sui Xiong Cai

John P Manfredi

Songchun Jiang

Christine A Klein

Andrew Gassman

Adam Willardsen

Kazuyuki Suzuki

J Adam Willardsen

Leena Bhoite

Matthew Reeder

Rachel Slade

The present disclosure relates to novel indole and tetrahydroindole core compounds useful for the treatment of disorders associated with a defect in vesicular transport (e.g., axonal transport).

Compounds for Alzheimer's disease

The invention provides novel compounds useful for the treatment of neurodegenerative disorders including Alzheimer's disease and dementia. The compounds have a substituents chosen from -L-C(&#x2550;O)OH, -L-CH&#x2550;CHC(&#x2550;O)OH, -L-C(&#x2550;O)NH, -L-C(&#x2550;O)NH(Calkyl), -L-C(&#x2550;O)N(Calkyl), -L-S(&#x2550;O)(Calkyl), -L-S(&#x2550;O)NH, -L-S(&#x2550;O)N(Calkyl), -L-S(&#x2550;O)NH(Calkyl), -L-C(&#x2550;O)NHOH, -L-C(&#x2550;O)CHNH, -L-C(&#x2550;O)CHOH, -L-C(&#x2550;O)CHSH, -L-C(&#x2550;O)NHCN, -L-NHC(&#x2550;O)OR, -L-C(&#x2550;O)NHR, -L-NH(C&#x2550;O)NHR, -L-C(&#x2550;O)N(R), -L-NH(C&#x2550;O)N(R), -L-sulfo, -L-(2,6 difluorophenol), -L-phosphono, and -L-tetrazolyl, where L is a linker.

Disclosed are 4-arylamino-quinazolines and analogs thereof that are effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Compounds and therapeutical use thereof

Disclosed are 1-arylamino-phthalazines, 4-arylamino-benzo[d][1,2,3]triazines, and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Pharmaceutical compounds as activators of caspases and inducers of apoptosis and the use thereof

Compounds for alzheimer's disease

An apparatus is provided for a bicycle lock assembly. A housing has an annular outer wall with a cable access slot and an integral rear wall. The rear wall supports a tubular inner wall that extends from the rear wall coaxially with the outer wall to define a torus shaped interior space. A reel provides a tubular core that is rotatably mounted onto the inner wall. The core supports a pair of spaced-apart guide walls which define a coiling space therebetween. A flexible cable is wound onto the reel between the guide walls. One end of the cable is fixed to the core. The other end of the cable extends through the access slot and includes a first lock mechanism. A coil spring has one end fixed to the annular outer wall and the other end fixed to the core of the reel. The spring lays in a spiral form adjacent to one of the guide walls such that rotation of the reel to unreel the cable causes the coil spring to tighten. Similarly, rotation of the reel to reel-in the cable causes the coil spring to loosen. A housing cover is fixed to the open side of the housing to enclose the housing. The cover has a central hole aligned with the inside diameter of the core so that the housing may be placed onto a tubular member of a bicycle. The housing is then retained on the tubular member of the bicycle by a bicycle seat. The housing has a second lock mechanism, and the two lock mechanisms are engagably lockable such that the housing, and therefore the bicycle, may be secured to a fixed object.

Bicycle lock with storable reel cable

Growing community of inventors

Salt Lake City, UT, United States of America

Robert J Halter