Macrochem Corporation

Cpex Pharmaceuticals, Inc.

White Mountain Pharma, Inc.

Robert J Gyurik

Carlos M Samour

Carl Reppucci

Scott F Krauser

Hillary D White

Topical alcoholic or aqueous alcoholic gels containing ibuprofen or other NSAIDs, such as, naproxen, in substantially neutral salt form, have enhanced penetration through skin and may provide rapid pain/inflammation relief by including in the formulation 2-n-nonyl-1,3-dioxolane or other hydrocarbyl derivative of 1,3-dioxolane or 1,3-dioxane or acetal, as skin penetration enhancing compound. The amount of propylene glycol may be varied to adjust the initial flux of the NSAID through the skin, especially for ibuprofen, naproxen, and ketorolac.

Non-steroidal antiinflammtory drug formulations for topical application

Topical alcoholic or aqueous alcoholic gels containing testosterone, progesterone, estradiol or other hormones have enhanced penetration through skin by including in the formulation 2-n-nonyl-1,3-dioxolane or other hydrocarbyl derivative of 1,3-dioxolane or 1,3-dioxane or acetal, as skin penetration enhancing compound.

Hormone replacement therapy drug formulations for topical application to

A composition for the topical transdermal administration to the penis is based on prostaglandin E.sub.1. The composition is non-irritating and effective for relieving erectile impotence or other penile erectile dysfunction. A penetration enhancing effective amount of a dioxolane, dioxane, or acetal skin penetration enhancing compound in a pharmaceutically acceptable aqueous alcoholic carrier is used to facilitate the penetration of the prostaglandin E.sub.1 active ingredient through the skin. Phentolamine or prazosin may be used in combination with prostaglandin E.sub.1.

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Exeter, NH, United States of America

Robert J Gyurik